A Rare Case of Pelvic Organ Prolapse in a Nulliparous Female With Autosomal Dominant Polycystic Kidney Disease (ADPKD) and Polycystic Liver Disease (PLD)

Abstract

Polycystic liver disease (PLD) is a condition that most often occurs in patients with autosomal dominant polycystic kidney disease (ADPKD) and less commonly as isolated liver disease. The presence of both conditions has proven to be a therapeutic challenge. Patients with ADPKD can suffer from significant renal and extra-renal complications and symptoms as a result of space-occupying cysts from polycystic kidney and liver enlargement. We present a case of ADPKD in a 56-year-old Caucasian female who developed pelvic organ prolapse, a rare complication, while also dealing with multiple other complications of ADPKD. Despite the high prevalence of ADPKD, complications such as pelvic organ prolapse have seldom been reported and discussed in the literature. The care team should do a prompt gynecological examination when they realize the burden of cysts becomes so large.

Clinical findings, underlying pathogenetic processes and treatment of vascular dysfunction in autosomal dominant polycystic kidney disease

“…Liver cysts were found in almost 85% of patients over the age of 30 years in the CRISP cohort at baseline [ 62 ]. Polycystic liver disease (PLD) is a disease most commonly seen in patients with ADPKD and less commonly as isolated liver disease [ 63 ]. Patients with ADPKD may have a large number of cysts in the liver, resulting in enlargement of the liver, compression of surrounding organs and tissues, abdominal pain, bloating, pressure, loss of appetite, changes in body image and physical discomfort, as well as mental discomfort [ 64 ].…”