A rare case of pancytopenia causing‐ Sheehan's syndrome: Case report and literature review

Abstract

We describe the case of a 58-year-old woman who was presented with pancytopenia and hypofibrinogenemia. Treatment with iron supplementation was not satisfactory. Physical findings and a history of a massive postpartum hemorrhage suggested Sheehan's syndrome(SS). After thyroxine and glucocorticoid replacement therapy, the blood cell count improved. SS is a rare etiology of hemocytopenia, of which hematologists need to be aware. We conclude that hormonal therapy can produce full hematological recovery.

Sheehan’s syndrome unveiled after decades without a diagnosis: A case report

“…1 The initial diagnosis relies on a comprehensive clinical history and physical examination, complemented by relevant laboratory tests and imaging studies, including the assessment of anterior pituitary hormone levels and pituitary magnetic resonance imaging, respectively. 4 In addition to hormonal irregularities, other manifestations of Sheehan's syndrome encompass hyponatremia (which is primarily caused by adrenal insufficiency, hypothyroidism, or syndrome of inappropriate antidiuretic hormone secretion), 9 hematologic abnormalities, such as anemia and, in some cases, pancytopenia, 10 osteoporosis, and impaired quality of life. 5 Here, we present this elderly female with severe hyponatremia and secondary hypothyroidism (low T4 and T3, with TSH in the lower limit of normal).…”