A rare case of mesenteric gastrointestinal stromal tumor presenting as acute abdomen

Ramani, Anant; Huske, Guruprasad; Noronha, F. P.

doi:10.4103/1117-6806.199960

Cited by 3 publications

(4 citation statements)

References 4 publications

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“… 1 - 4 These tumors can arise in any part of the GI tract, but a higher burden has been observed in the stomach and small intestines. 2 , 6 , 7 , 12 , 14 Although extremely rare, eGISTs have been identified in the uterus, urinary bladder, retroperitoneum, omentum, mesentery, liver, pancreas, and pleura. 14 - 16 Gastrointestinal stromal tumors are usually found in individuals over the age of 50 years, with a slight male predominance.…”

Section: Discussionmentioning

confidence: 99%

“…On very rare occasions, patients may present with peritonism or obstructive symptoms due to the compressive effect of the tumor. 6 Ulcerated or ruptured GISTs can present with GI bleeding or bowel perforation, prompting urgent surgical intervention. 15 …”

Section: Discussionmentioning

confidence: 99%

“…2 , 5 The term GIST was coined by Mazur and Clark in 1983, but it took 15 years for its etiopathogenesis to be understood. 1 - 3 , 6 - 10 In 1998, Japanese scientists found that gain-of-function mutations in KIT proto-oncogene receptor tyrosine kinase were critical for developing GISTs. 1 , 11 This critical discovery paved the way for more molecular studies and the expanded use of imatinib mesylate (IM; Gleevec, Novartis, Basel, Switzerland) in the treatment of advanced GISTs and later as adjuvant chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

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A Unique Case of Mesenteric Gastrointestinal Stromal Tumor Presenting as an Acute Abdomen

Bathobakae,

Bashir,

Vera

et al. 2024

Journal of Investigative Medicine High Impact Case Reports

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Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the digestive tract and arise from the interstitial cells of Cajal in the mesenteric plexus. These tumors can originate in any part of the GI tract; however, a higher burden has been observed in the stomach and small intestines. Mesenteric GISTs are exceedingly rare, with unique clinicopathological features and a poorer prognosis. Herein, we describe a unique case of a 66-year-old female with a remote history of appendectomy who presented to the emergency room complaining of severe abdominal pain and vomiting. On imaging, the patient was found to have a large inflammatory mass associated with small bowel loops, and the pathology confirmed a mesenteric GIST. The tumor was resected, and the genomic test results confirmed the KIT (exon 11) mutation. Although the tumor had a low mitotic rate, the tumor was large enough to warrant the initiation of adjuvant imatinib mesylate for 36 months with regular bloodwork and imaging.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Unique Case of Mesenteric Gastrointestinal Stromal Tumor Presenting as an Acute Abdomen

Bathobakae,

Bashir,

Vera

et al. 2024

Journal of Investigative Medicine High Impact Case Reports

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“…Symptomatic patients generally present with abdominal pain, abdominal distension, or abdominal mass. Cross-sectional imaging (US, CT, MRI) shows a solid or solid and cystic mass arising from the mesentery [125]. The tissue sample can be obtained by ultrasound-guided or CT-guided biopsy.…”

Section: Primary Mesenteric Desmoid Tumor (Mdt)mentioning

confidence: 99%

A New Organ: The Mesentery and Non-Vascular Mesenteric Diseases

Ahmed

2024

Preprint

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Mesentery was discovered as a new organ in 2017. It is a continuous membranous tissue from the duodenojejunal flexure to the anorectal junction. It has distinct anatomy, physiology, and disease states. Primary mesenteropathies include vascular and non-vascular diseases. Some of them are common, and some of them are rarely seen in clinical practice. Secondary mesenteropathies occur when infection or malignancy in another organ spreads to the mesentery. Each entity has specific diagnostic and treatment protocols.

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A Rare Case of Mesenteric Gastrointestinal Stromal Tumour (Gist) Presenting as Mesenteric Mass.

Javia

Desai

Patel

et al. 2020

Global Journal for Research Analysis

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Gastrointestinal stromal tumours (GIST) are rare tumours arising from mesenchyme of gastrointestinal tract and overexpress C-kit protein. Mainly seen in stomach and small bowel. Mesenteric GIST are rarely reported as they constitute less than 1% of total GIST. We hereby report such a rare case of GIST arising from mesentery of small bowel and presenting as intra-abdominal mesenteric mass. Good surgical clearance ensures good survival whereas incomplete resection results in a high incidence of recurrences with distant metastasis.

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A rare case of mesenteric gastrointestinal stromal tumor presenting as acute abdomen

Cited by 3 publications

References 4 publications

A Unique Case of Mesenteric Gastrointestinal Stromal Tumor Presenting as an Acute Abdomen

A Unique Case of Mesenteric Gastrointestinal Stromal Tumor Presenting as an Acute Abdomen

A New Organ: The Mesentery and Non-Vascular Mesenteric Diseases

A Rare Case of Mesenteric Gastrointestinal Stromal Tumour (Gist) Presenting as Mesenteric Mass.

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