A Rare Case of Leiomyosarcoma of Cervix and challenges in its management.

Mehra, Reeti; Sidhu, Sukhbir; Pandey, Awadhesh Kumar; Garg, Sanjeev

doi:10.5455/2320-6012.ijrms20150161

Cited by 4 publications

(7 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Surgery is the main treatment option. Total abdominal hysterectomy, bilateral salpingo-oophorectomy with or without omentectomy and lymph node dissection are the preferred options for women with LMS of the uterus (3,7,8). Our patient had polypectomy of the cervical LMS which is an unusual treatment option with a complete excision.…”

Section: Discussionmentioning

confidence: 84%

“…Studies in Nigeria quoted an incidence of 0.5% (2). This tumor can arise primarily from the cervix given its extreme rarity (3,7). Patients with LMS are usually postmenopausal, at an average age of 60 years (7), and tend to present with non-specific symptoms which may include abnormal vaginal bleeding and discharge.…”

Section: Discussionmentioning

confidence: 99%

“…Our patient had polypectomy of the cervical LMS which is an unusual treatment option with a complete excision. Adjuvant chemotherapy using gemcitabine and docetaxel have also been reported (3,7). This therapy with or without radiation therapy can result in the prolonged survival and cure.…”

Section: Discussionmentioning

confidence: 99%

“…Frequency of cervical malignancies occurring due to sarcomas are fewer than 1% (1)(2)(3)(4), which commonly occur in the perimenopausal (5) and postmenopausal women with quite a small number of reported cases of LMS amongst young women (3,4). LMS usually affects the uterine corpus, metastasizing to other peritoneal organs and even beyond.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Polypectomy as a Complete Therapy for Leiomyosarcoma of the Cervix Uteri: An Unusual Treatment

Aminu

Dattijo

Abdullahi

et al. 2017

International Journal of Women’s Health and Reproduction Scienc

View full text Add to dashboard Cite

Objectives: Leiomyosarcoma (LMS), which arises from the uterine cervix, is an extremely rare neoplasm and is presented with vaginal bleeding and discharge. In our case report, we intended to highlight the role of polypectomy as a practical option for routine hysterectomy and the surgical cure of cervical LMS. Case Report: A 50-year-old woman (Para 8+0, 6A) presented to the Gynecological Clinic of ATB University Teaching Hospital with vaginal discharge and fleshy mass protruding from the vulva. Examination revealed a cervical polyp on the anterior lip of the cervix. Polypectomy was performed subsequently, and histologic examination including immunohistochemical staining confirmed LMS of the uterine cervix. The patient underwent hysterectomy with bilateral salpingo-oophorectomy with the histological confirmation of a complete excision. Conclusions: Generally, no specific management option is taken for this tumor due to its rare occurrence. However, polypectomy with a wide excision of tumor margin could result in a complete cure, and prolonged survival as in the case presented. Accordingly, histological studies including special stainings may play a vital role in cancer diagnosis.

show abstract

Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Polypectomy as a Complete Therapy for Leiomyosarcoma of the Cervix Uteri: An Unusual Treatment

Aminu

Dattijo

Abdullahi

et al. 2017

International Journal of Women’s Health and Reproduction Scienc

View full text Add to dashboard Cite

show abstract

“…Leiomyosarcoma of the cervix is very rare and occurs mostly in premenopausal women (5). Diagnosis before surgery is a rare occurrence (6). In leiomyosarcoma of the uterine corpus, involvement of the cervix is not uncommon, so for definite diagnosis of primary cervical leiomyosarcoma, the bulk of the tumor should be on the cervix but not the isthmus (1).…”

Section: Discussionmentioning

confidence: 99%

Cervical Leiomyosarcoma: A Case Report

Aminimoghaddam

Arabian

Haghighi

et al. 2016

J Obstet Gynecol Cancer Res

View full text Add to dashboard Cite

Introduction: Sarcoma of the cervix is uncommon and its prevalence is about 1% of malignancies of the cervix. One type of sarcoma is leiomyosarcoma and the location of this tumor in cervix is very rare. Although uterine sarcoma can involve the cervix and lead to misdiagnosis of cervical leiomyosarcoma, the location of the bulk of the tumor in uterine cervix (not isthmus) for diagnosis of cervical leiomyosarcoma is mandatory. The origin of sarcoma is from mesodermal tissue. Due to the rarity of cervical leiomyosarcoma and response to debulking surgery after recurrence, report of this case is interesting. Case Presentation: We hereby report on a 34-year-old unmarried patient, who was a known case of leiomyosarcoma of uterine cervix that was referred with recurrence of tumor in parietal peritoneum, retropobic retzius space and around the bladder and ureter and sigmoid colon. The patient was treated with debulking surgery of the tumor and chemotherapy. Conclusions: Sarcoma as a genital tract malignancy is very rare and the location of sarcoma at pediatric age is in the vagina and at middle age is in the cervix and at postmenopausal women in the uterine corpus. Cervical sarcoma as a rare tumor of the cervix arises from stromal tissue. Due to hematogenous spread of sarcoma, metastasis in lungs is seen and recurrence of this tumor is not uncommon. In this article, recurrence of a known case with leiomyosarcoma of uterine cervix in previous hysterectomy that responded to debulking surgery with removal of metastatic lesions in peritoneal and retroperitoneal spaces and adjuvant therapy with standard chemotherapy drugs and monoclonal antibody therapy is reported. Due to non-hormonal dependence of sarcoma to hormonal secretion from the ovaries and benefit of the ovaries in young women for protection of bone health and cardiovascular system, oophorectomy is a challenging idea and an issue of debate, thus primary surgery, in this case oophorectomy, was not done.

show abstract