A rare case of invasive sino-orbital aspergillosis arising from isolated frontal sinus infection

Halliday, Luke; Curragh, David; Selva, Dinesh

doi:10.1016/j.jcjo.2018.04.022

Cited by 4 publications

(3 citation statements)

References 15 publications

(22 reference statements)

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“…Debulking along with prolonged antifungal therapy can be effective in controlling the infection; in addition to retrobulbar amphotericin B injection [ 10 ]. Our case did not require exenteration unlike other reports [ 11 ]; this may be due to the more anterior location of the mass.…”

Section: Discussioncontrasting

confidence: 48%

Frontal sinus infection leading to sino-orbital aspergillosis: a case report

Yvon¹,

Abdulla²,

Watson³

et al. 2021

Pan Afr Med J

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Sino-orbital aspergillosis is an uncommon but aggressive infection. It rarely originates from the frontal sinus due to the complex anatomy of the frontal recess and anteromedial position of its ostium. An 87-year-old man of Nigerian heritage with a history of multiple myeloma, chronic kidney disease and type 2 diabetes, presented to the eye clinic with a right tense swollen eyelid and proptosis. Computed tomography (CT) and magnetic resonance imaging (MRI) scan revealed a right superomedial mass communicating with the frontal sinus and biopsy confirmed an orbital aspergilloma. The patient was successfully treated with debulking surgery and anti-fungal treatment despite developing side effects to the drugs. To improve prognosis, ophthalmologists should be aware of this distinct entity and use a multi-disciplinary approach.

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Section: Discussioncontrasting

confidence: 48%

Frontal sinus infection leading to sino-orbital aspergillosis: a case report

Yvon¹,

Abdulla²,

Watson³

et al. 2021

Pan Afr Med J

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“…His patient underwent exenteration and received intravenous amphotericin B and voriconazole. The patient was died 3 months after initial presentation due to intracranial abscess, despite the treatment [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Invasive maxillary aspergillosis in a patient with systemic lupus erythematosus: Case report

Dachlan

Wicaksana

Fauzi

et al. 2020

Annals of Medicine and Surgery

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Introduction Invasive aspergillosis (IA) is a fungal infection caused by Aspergillus species (spp.). Aspergillosis is the most common source of opportunistic fungal infection in humans. IA can cause serious complications related to high morbidity and mortality in immunocompromised patients. Presentation of case We report a case of a 22-year-old female with a chief complaint of having a hole in the roof of her mouth. She was diagnosed with SLE in 2009. She had been consuming oral methylprednisolone ever since. In 2018, she experienced worsened symptoms and was hospitalized. She experienced swelling and bleeding of her gums and some of her teeth becoming loose and falling out, and then developing a hole in the roof of her mouth. Subsequently, she was treated with oral cyclophosphamide, oral mycophenolate sodium, and oral fluconazole. She was asked to stop taking oral methylprednisolone. In 2019, the palate biopsy was performed and showed Aspergillus spp. invading the palate. Afterward, the patient was referred to our clinic for defect closure. The patient was operated on for debridement and reconstruction of the defect. There was no recurrence of the defect or complications observed in the follow-up. The patient was satisfied with the surgical results. Discussion IA is a destructive and potentially harmful opportunistic fungal infection and treatments with surgical interventions should be well-thought-out in immunocompromised patients. Conclusion The management of IA are controlling any underlying diseases and surgical debridement or necrotomy. Generally, antifungal therapy and prompt surgical intervention are successful in managing invasive aspergillosis.

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“…Initial presentation of invasive aspergillosis is often after the orbit or cranial vault have been invaded. Bony erosion allows the spread of fungal infection to these structures, and is thought to result from increased pressure, demineralization of bone, or expansion of fungal mass [7][8][9]. Intra-cranial involvement may occur by direct extension through the superior orbital fissure, hematogenous spread, or erosion through the affected sinus [9].…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Sino-Orbital Invasive Aspergillosis in a Kidney Transplant Recipient

Mattiazzi¹,

Cortesi²,

Lavi³

et al. 2020

TCR

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Invasive sino-orbital aspergillosis is an uncommon but potentially life-threating complication of kidney transplantation. Here we report a case of a patient with invasive aspergillus fumigatus sinusitis extending into the orbit in a kidney transplant recipient who was successfully treated with voriconazole and surgical debridement without requiring orbital exenteration. This case illustrates a rare but life-threatening complication of immunosuppression that highlights the importance of suspecting and promptly recognizing fungal infection of the sinuses in vulnerable organ transplant recipients in order to avoid significant morbidity and mortality.

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A rare case of invasive sino-orbital aspergillosis arising from isolated frontal sinus infection

Cited by 4 publications

References 15 publications

Frontal sinus infection leading to sino-orbital aspergillosis: a case report

Frontal sinus infection leading to sino-orbital aspergillosis: a case report

Invasive maxillary aspergillosis in a patient with systemic lupus erythematosus: Case report

A Rare Case of Sino-Orbital Invasive Aspergillosis in a Kidney Transplant Recipient

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