A Rare Case of Invasive Apocrine Carcinoma of the Breast with Unusual Radiologic Findings

Kim, Ji Min; Kim, Shin Young; Oh, Mee‐Hye; Lee, Jong Eun

doi:10.5812/iranjradiol.35298

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…Table 2 shows a summary of the published articles reporting the imaging findings of patients with malignant apocrine lesions, and these findings are in line with our results [ 8 9 10 11 12 13 14 15 16 ]; therefore, the radiologic features of carcinoma with apocrine differentiation or ADCIS did not differ from those of typical invasive carcinoma of non-special-type or DCIS. However, invasive carcinoma presented more obvious mass formation on imaging compared with in situ lesions.…”

Section: Resultssupporting

confidence: 88%

Malignant Apocrine Lesions of the Breast: Multimodality Imaging Findings and Biologic Features

et al. 2022

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The apocrine morphology of the breast is observed in a broad pathological spectrum, ranging from benign cysts to invasive carcinomas. However, the number of clinical research investigating malignant apocrine lesions is limited. This study retrospectively reviewed the data of patients with malignant apocrine lesions admitted in a tertiary center between January 2004 and December 2021, based on the radiology-pathology correlation and the recent advances in their status to enhance the therapeutic implications of androgen receptor (AR). Among the 37 patients with lesions, 27 (73.0%) had triple-negative subtypes with predominant AR expression. The radiological features of malignant apocrine lesions did not differ from those of typical invasive ductal carcinoma or ductal carcinoma in situ. This study demonstrated that knowledge on the imaging features of malignant apocrine lesions and their histological basis could enhance the adoption of new targeted therapies in patients with this particular type of breast cancer.

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Section: Resultssupporting

confidence: 88%

Malignant Apocrine Lesions of the Breast: Multimodality Imaging Findings and Biologic Features

et al. 2022

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Triple-negative apocrine carcinoma as a rare cause of a breast lump in a Syrian female: a case report and review of the literature

et al. 2021

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Background Apocrine carcinoma is a rare tumor that constitutes < 4% of all breast malignancies, characterized by the proliferation of large atypical cells with strictly defined borders, abundant eosinophilic cytoplasm, large nuclei, and prominent nucleoli in more than 90% of tumor cells. Triple-negative apocrine carcinoma is a rare molecular subtype that constitutes less than 1% of triple-negative breast cancers and is characterized by negative expression of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor, with positive expression of androgen receptor. Case presentation We report a case of a 45-year-old Syrian female who presented to our hospital due to a painless palpable mass in her left breast. Following physical and radiological examinations, an excisional biopsy was performed. Microscopic examination of the specimen followed by immunohistochemical staining revealed the diagnosis of a triple-negative apocrine carcinoma. Conclusion Triple-negative apocrine carcinoma is an extremely rare neoplasm that must be considered in the differential diagnoses of breast lesions through detailed clinical, histological, and immunohistochemical correlations. In our manuscript, we aimed to present the first case report of a Syrian female who was diagnosed with a triple-negative apocrine carcinoma, aiming to highlight the importance of detailed clinical, histological and immunohistochemical correlations with a detailed review of diagnostic criteria, molecular characteristics, and treatment recommendations.

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A Rare Case of Invasive Apocrine Carcinoma of the Breast with Unusual Radiologic Findings

Cited by 2 publications

References 8 publications

Malignant Apocrine Lesions of the Breast: Multimodality Imaging Findings and Biologic Features

Malignant Apocrine Lesions of the Breast: Multimodality Imaging Findings and Biologic Features

Triple-negative apocrine carcinoma as a rare cause of a breast lump in a Syrian female: a case report and review of the literature

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