A rare case of intravascular epithelioid hemangioendothelioma of the cephalic vein treated with surgery and postoperative radiation therapy: a case report and review of the literature

Abstract

IntroductionEpithelioid hemangioendothelioma (EHE) is a rare endothelial tumor with an intermediate grade of malignancy. Few cases of primary vascular hemangioendothelioma have been described in the literature. Surgery is the treatment of choice, but radiation therapy and chemotherapy should also be considered in particular cases.Case presentationWe present the case of a 44-year-old Caucasian woman affected by EHE of the cephalic vein, treated by complete surgical removal of the mass and postoperative local radiation therapy. At 5-year follow-up, our patient is alive, with no signs of local or distant relapse and with no late radiation-related effects.ConclusionsPostoperative radiotherapy may play a role in cases in which tumor margins are close or cannot be assessed or when high-risk features are present.

Epithelioid hemangioma involving large arteries in the skin

“…In addition, an intravascular location is extremely rare for EHE. [17][18][19][20] Given the lack of cytologic atypia and the presence of adjacent area of conventional EH, our case is best classified as EH involving large arteries.…”

Application of Ultrahigh Doses of Morphine in Systemic Multiple Epithelioid Hemangioendothelioma without Addiction: A Case Report

“…Surgical resection is one of the effective ways to treat EHE [17] [18]. It is reported that the 5-year survival rate after surgical excision is approximately 75% [19], and this provides a good basis for patients to choose surgical treatment.…”

Clinico‐radiological features and next generation sequencing of pulmonary epithelioid hemangioendothelioma: A case report and review of literature

“…The development of the electron microscope and immunohistochemical techniques confirmed the endothelial lineage of the tumor cells and the term epithelioid hemangioendothelioma was coined in 1986 . Clinically, EH is a rare vascular tumor with low to borderline malignancy between a benign hemangioma and a malignant angiosarcoma . It is reported to arise from many organ systems, including the liver, bone, soft tissue, mediastinum, and lungs …”

“…4 Clinically, EH is a rare vascular tumor with low to borderline malignancy between a benign hemangioma and a malignant angiosarcoma. 5,6 It is reported to arise from many organ systems, including the liver, bone, soft tissue, mediastinum, and lungs. 7,8 The mortality rate associated with EH varies according to the location of the tumor, reported as 13% in soft tissue, 35% in the liver, and 65% in lung tumors.…”