A Rare Case of Gastric Fundic Gland Adenocarcinoma (Chief Cell Predominant Type)

Chen, Wei‐Chung; Rodriguez‐Waitkus, Paul; Barroso, Alberto O.; Balsaver, Ashok M.; McKechnie, John C.

doi:10.1007/s12029-012-9416-z

Cited by 14 publications

(17 citation statements)

References 11 publications

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“…Gastric chief cell‐predominant lesions are rare and, to date, only 29 cases have been published in the English literature. This includes 17 cases of GA‐FG and 12 cases described as OGP (Table ) . The majority of GA‐FG were in Asian patients [Japanese patients ( n = 13) and Korean ( n = 3)], while OGP were distributed more equally among ethnic groups (four Hispanic, two Caucasian, two African American, one Chinese and three of unknown ethnicity) …”

Section: Discussionmentioning

confidence: 99%

“…A common denominator of these lesions appears to be the exclusive location in the oxyntic‐type gastric mucosa. The mixed composition of chief and oxyntic cells is recognized by all, as is the absence of or slow progression in these cases . A link to pyloric gland origin has also been proposed recently on the basis of common biologic abnormalities …”

Section: Introductionmentioning

confidence: 97%

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Chief cell‐predominant gastric polyps: a series of 12 cases with literature review

Chan

Brown

Kyle³

et al. 2015

Histopathology

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Chief cell‐predominant gastric polyps: a series of 12 cases with literature review

Chan

Brown

Kyle³

et al. 2015

Histopathology

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“…Recently, our group [1] and others [2,3,4] described a new histologic variant of gastric cancer termed gastric adenocarcinoma of fundic gland type (GAFG). This type of tumor manifests as solitary, small, and well-circumscribed lesions extending into the submucosa in the upper third portion of the stomach.…”

Section: Introductionmentioning

confidence: 99%

“…This type of tumor manifests as solitary, small, and well-circumscribed lesions extending into the submucosa in the upper third portion of the stomach. Histologically, the lesions are composed of tightly packed glands and cords, which are predominantly comprised of chief cells exhibiting anisonucleosis and lacking chronic gastritis, atrophic change, or intestinal metaplasia in their surrounding mucosa [1,2,3,4]. Based on the common occurrence of GAFG and the sporadic fundic gland polyp with frequent mutations in CTNNB1 in the fundic glands, these tumors have been hypothesized to display constitutive activation of the Wnt/β-catenin signaling pathway.…”

Section: Introductionmentioning

confidence: 99%

Distinct Involvement of the Sonic Hedgehog Signaling Pathway in Gastric Adenocarcinoma of Fundic Gland Type and Conventional Gastric Adenocarcinoma

Tajima

Murakami²,

Saito³

et al. 2017

Digestion

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Background/Aims: Gastric adenocarcinoma of fundic gland type (GAFG), which is a rare variant of gastric cancer, is reportedly associated with both Wnt/β-catenin signaling activation and guanine nucleotide binding protein, alpha stimulating complex (GNAS) mutations. This study aimed to elucidate potential roles of the Sonic hedgehog (Shh) signaling pathway in GAFG. Methods: We performed immunostaining for β-catenin and Shh signal-associated proteins, including Patched (Ptch), Smoothened (Smo), and Glioma-associated oncogene-1 (Gli1), and the direct sequencing of GNAS/BRAF/KRAS in 27 GAFGs, and compared them with 30 conventional gastric adenocarcinomas (CGAs). Results: GAFGs exhibited significantly lower immunoreactivity scores for Ptch, Smo, and Gli1 than CGAs. Moreover, while the Ptch score was significantly lower in the GAFG tumor areas than in the non-neoplastic areas adjacent to GAFG, the score was significantly higher in the CGA tumor areas than in the non-neoplastic areas. Similar trends were observed in the scores for Smo and Gli1. β-Catenin expression and GNAS mutations were found in 22 (81%) and 8 (30%) of the 27 GAFGs respectively. Gli1 expression was significantly associated with mutations in GNAS. Conclusion: GAFG and CGA exhibited distinct Ptch, Smo, and Gli1 expression patterns. Downregulation of the Shh signaling pathway, as well as activation of the Wnt/β-catenin signaling pathway, may therefore be associated with tumorigenesis in GAFG.

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“…Gastric adenocarcinoma of fundic gland (chief cell predominant type) is defined as a neoplasm that mainly consists of highly differentiated columnar epithelial cells resembling the fundic gland cells, mainly chief cells, with nuclear atypia. Although incidence of this type of cancer seems to be low (1.6% of gastric adenocarcinoma) [10] , recently, several case series have been published in Japan [11] and other countries [12][13][14] .…”

Section: Introductionmentioning

confidence: 99%

Endoscopic features of early stage gastric adenocarcinoma of fundic gland type (chief cell predominant type): a case report

Fujii

Uedo

Ishihara

et al. 2014

CRCP

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A 64-year-old Helicobacter pylori infection-naïve woman was found to have a small (≤ 10 mm) depression on the anterior wall of the upper gastric body. On white light endoscopy, the lesion appeared to be inconspicuous, whitish with dilated vessels. 0.2% indigo carmine chromoendoscopy enable better visualization of the depression. On narrow band imaging with magnification, the microsurface structure of the surrounding mucosa was absent and a network of tortuous microvessels were observed within the depressed area. Endoscopic ultrasonography indicated that the tumor was confined to the mucosa. The lesion was removed by endoscopic submucosal dissection. Histological finding of the resected specimen revealed that carcinomatous tubules existed in the deep part of the lamina propria with minimal (300 μm) submucosal invasion which were covered with the atrophic non-neoplastic foveolar epithelium. The tumor was diffusely positive for MUC6 and pepsinogen-I, while it was negative for MUC5AC and H+/K+-ATPase. A diagnosis of early stage gastric adenocarcinoma of fundic gland type (chief cell predominant type) was made.

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A Rare Case of Gastric Fundic Gland Adenocarcinoma (Chief Cell Predominant Type)

Cited by 14 publications

References 11 publications

Chief cell‐predominant gastric polyps: a series of 12 cases with literature review

Chief cell‐predominant gastric polyps: a series of 12 cases with literature review

Distinct Involvement of the Sonic Hedgehog Signaling Pathway in Gastric Adenocarcinoma of Fundic Gland Type and Conventional Gastric Adenocarcinoma

Endoscopic features of early stage gastric adenocarcinoma of fundic gland type (chief cell predominant type): a case report

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