A Rare Case of Fusobacterium necrophorum Liver Abscesses

Hannoodi, Faris; Sabbagh, Hussam; Kulairi, Zain; Kumar, Sarwan

doi:10.4081/cp.2017.928

Cited by 11 publications

(13 citation statements)

References 14 publications

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“…Several studies have identified increased abundances of the oral microbe Fusobacterium in setting of colorectal cancer ( 29 , 33 – 35 ), liver cirrhosis ( 36 – 38 ), primary sclerosing cholangitis ( 39 – 41 ), gastroesophageal reflux disease ( 42 – 46 ), HIV infection ( 47 – 49 ), alcoholism ( 50 ), and IBD ( 6 , 10 – 19 ). Given the prevalence of F. nucleatum in mucosal specimens, we tested the hypothesis that this pathobiont could promote an epithelial proinflammatory response and potentially contribute to intestinal inflammation.…”

Section: Resultsmentioning

confidence: 99%

Fusobacterium nucleatum Secretes Outer Membrane Vesicles and Promotes Intestinal Inflammation

Engevik

Danhof

Ruan

et al. 2021

mBio

133

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Multiple studies have implicated microbes in the development of inflammation, but the mechanisms remain unknown. Bacteria in the genus Fusobacterium have been identified in the intestinal mucosa of patients with digestive diseases; thus, we hypothesized that Fusobacterium nucleatum promotes intestinal inflammation. The addition of >50 kDa F. nucleatum conditioned media, which contain outer membrane vesicles (OMVs), to colonic epithelial cells stimulated secretion of the proinflammatory cytokines interleukin-8 (IL-8) and tumor necrosis factor (TNF). In addition, purified F. nucleatum OMVs, but not compounds <50 kDa, stimulated IL-8 and TNF production; which was decreased by pharmacological inhibition of Toll-like receptor 4 (TLR4). These effects were linked to downstream effectors p-ERK, p-CREB, and NF-κB. F. nucleatum >50-kDa compounds also stimulated TNF secretion, p-ERK, p-CREB, and NF-κB activation in human colonoid monolayers. In mice harboring a human microbiota, pretreatment with antibiotics and a single oral gavage of F. nucleatum resulted in inflammation. Compared to mice receiving vehicle control, mice treated with F. nucleatum showed disruption of the colonic architecture, with increased immune cell infiltration and depleted mucus layers. Analysis of mucosal gene expression revealed increased levels of proinflammatory cytokines (KC, TNF, IL-6, IFN-γ, and MCP-1) at day 3 and day 5 in F. nucleatum-treated mice compared to controls. These proinflammatory effects were absent in mice who received F. nucleatum without pretreatment with antibiotics, suggesting that an intact microbiome is protective against F. nucleatum-mediated immune responses. These data provide evidence that F. nucleatum promotes proinflammatory signaling cascades in the context of a depleted intestinal microbiome. IMPORTANCE Several studies have identified an increased abundance of Fusobacterium in the intestinal tracts of patients with colon cancer, liver cirrhosis, primary sclerosing cholangitis, gastroesophageal reflux disease, HIV infection, and alcoholism. However, the direct mechanism(s) of action of Fusobacterium on pathophysiological within the gastrointestinal tract is unclear. These studies have identified that F. nucleatum subsp. polymorphum releases outer membrane vesicles which activate TLR4 and NF-κB to stimulate proinflammatory signals in vitro. Using mice harboring a human microbiome, we demonstrate that F. nucleatum can promote inflammation, an effect which required antibiotic-mediated alterations in the gut microbiome. Collectively, these results suggest a mechanism by which F. nucleatum may contribute to intestinal inflammation.

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Section: Resultsmentioning

confidence: 99%

Fusobacterium nucleatum Secretes Outer Membrane Vesicles and Promotes Intestinal Inflammation

Engevik

Danhof

Ruan

et al. 2021

mBio

133

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“…There are three reported cases of P. micra causing hepatic abscesses and none with a mixture Parvimonas and Fusobacterium [ 3 , 6 – 14 ]. Our case was similar in presentation with other studies, with chief presenting symptoms of fever, chills, GI upset, and abdominal pain, worsening over a course of several weeks prior to diagnosis [ 6 , 7 , 14 ].…”

Section: Discussionmentioning

confidence: 99%

“…Fusobacterium bacteremia is rare, comprising less than 1% of all bacteremia and less than 10% of anaerobic bacteremia [ 1 ]. There are case reports of hepatic abscesses caused by Fusobacterium , most of which are caused by hematogenous spread from either odontogenic infection or inflammation of the GI tract [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

P. micra and F. necrophorum: Hepatic Abscesses in a Healthy Soldier

Strobel

Whitaker

Choi

et al. 2022

Case Reports in Infectious Diseases

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Parvimonas micra (P. micra) and Fusobacterium necrophorum (F. necrophorum) are two pathogens known to cause odontogenic and oropharyngeal infections. It is exceedingly rare for these bacteria to cause coinfection and even systemic infection. There is limited literature on liver abscesses and bacteremia involving P. micra. Most cases are found in elderly patients with associated gastrointestinal malignancy (24%) or laryngeal pharynx malignancy (28%). However, a substantial portion of described cases were unable to identify a source (36%). A 36-year-old, otherwise healthy male presented for fevers and chills for 2 weeks. After testing negative for initial infectious workup, including COVID-19 multiple times, he was found to have multiple liver abscesses which grew P. micra and F. necrophorum. This case highlights a rare coinfection of hepatic abscesses in an otherwise healthy young immunocompetent adult with a solitary dental caries, resulting in septic shock.

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“…It is a rare cause of liver abscesses and intracerebral infections. F. necrophorum is known for its association with Lemierre’s syndrome, a rare oropharyngeal infectious disease-causing septic thrombophlebitis of the internal jugular vein seen mostly in young immunocompromised patients [ 6 ]. Bacteremia with Fusobacterium spp.…”

Section: Discussionmentioning

confidence: 99%

Fatal Case of Liver and Brain Abscesses Due to Fusobacterium nucleatum

Toumeh¹,

Mudireddy²,

Smith³

et al. 2021

Cureus

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Fusobacterium nucleatum is an anaerobic gram-negative organism regarded as an oral commensal. We present a case of a 63-year-old male presenting with weakness, encephalopathy and right upper quadrant palpable mass found to have F. nucleatum liver abscess with innumerable intracranial abscesses. F. nucleatum is a rare cause of concomitant liver and brain abscesses associated with odontogenic infection with potentially fatal outcomes.

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A Rare Case of Fusobacterium necrophorum Liver Abscesses

Cited by 11 publications

References 14 publications

Fusobacterium nucleatum Secretes Outer Membrane Vesicles and Promotes Intestinal Inflammation

Fusobacterium nucleatum Secretes Outer Membrane Vesicles and Promotes Intestinal Inflammation

P. micra and F. necrophorum: Hepatic Abscesses in a Healthy Soldier

Fatal Case of Liver and Brain Abscesses Due to Fusobacterium nucleatum

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