A Rare Case of Endocervical Adenocarcinoma of Gastric Type

Abstract

Gastric adenocarcinoma of the cervix (GAC) represents a rare mucinous endocervical cancer unrelated to human papillomavirus (HPV). GAC has been found to comprise approximately 10% of cervical adenocarcinomas internationally. As more cases have been identified, GAC has been further classified into subtypes such as poorly differentiated versus well-differentiated (also referred to as mucinous or adenoma malignum). This cancer coined the term "gastric" subtype due to its similarity to the pancreaticobiliary and gastric tissue lining. With limited data and similar histological and genetic features of GAC, this malignancy poses a challenge for clinicians when differentiating between metastasis from the gastrointestinal tract and GAC. Here, we present a case of a 55-year-old female who presented with postmenopausal bleeding and was found to have stage IA1 endocervical adenocarcinoma of gastric subtype. The purpose of this article is to introduce a rare type of gastric adenocarcinoma with a unique site of origin in order to better understand this disease process and potentially help clinicians better diagnose and treat patients with this malignancy in the future.

Intestinal adenocarcinoma of the uterine cervix with gastrointestinal metastasis

“…Regarding chemotherapy for patients with GAC, one study used therapeutic options such as Paclitaxel/Carboplatin, Irinotecan and Tegafur/Imeracil/Oteracile therapies, with the selection of agents depending on cancer staging and mainly with treatment in the adjuvant setting. 1,11,12…”