A Rare Case of Crohn’s Disease Manifesting as a Large Liver Abscess

Jain, Akriti G; Faisaluddin, Mohammed; Gllava, Idljona; Gordon, Dwayne; Guan, Jian

doi:10.7759/cureus.3758

Cited by 4 publications

(6 citation statements)

References 8 publications

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“…Dissemination through portal circulation is another postulated mechanism from which hepatic abscess might primarily originate. [ 11 ] Malnutrition seems to be a contributing factor; however, the exact predisposition has yet to be determined. The majority of patients with IBD experience a prolonged physiologic state of catabolism that can weaken the immunity and reduce their quality of life.…”

Section: Discussionmentioning

confidence: 99%

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Hepatic abscess in inflammatory bowel disease: A systematic scoping review of an overlooked entity

Alshammary,

Boumarah

2023

Saudi J Med Med Sci

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Background: Liver abscess is one of the hepatobiliary manifestations of inflammatory bowel disease (IBD) that has been scarcely described in the literature. Objectives: To conduct a scoping review to provide a detailed description of the occurrence of hepatic abscess in patients with IBD and summarize the observed clinical features. Methodology: Searches were carried out using relevant keywords in Medline (via PubMed) and Web of Science from inception until June 13, 2022. Only articles that reported the occurrence of hepatic abscess in patients with IBD were included. Results: Forty-eight publications (40 case reports and 8 case series) were included, representing 73 patients with IBD who were radiologically or intraoperatively diagnosed with hepatic abscess. Patients with Crohn’s disease were more predisposed to developing hepatic abscess than patients with ulcerative colitis (79.5% vs. 20.5%, respectively). Furthermore, pyogenic liver abscess was found to be more prevalent (57.9%) compared with aseptic (38.7%) and amebic (3.2%) abscesses. No clear relation was found between death or prolonged hospital stay in terms of the clinical presentation or management plan, as mortality was reported in different age groups with different managements. Conclusion: To date, there is no consensus regarding the appropriate management of hepatic abscess as an extraintestinal manifestation of IBD. However, the condition shares several features with liver abscess diagnosed among the general population.

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Section: Discussionmentioning

confidence: 99%

“…It has been postulated that the state of immunosuppression, established among most IBD patients, and alteration of normal gut flora play a pivotal role in liver abscess development. [ 11 ]…”

Section: Introductionmentioning

confidence: 99%

Hepatic abscess in inflammatory bowel disease: A systematic scoping review of an overlooked entity

Alshammary,

Boumarah

2023

Saudi J Med Med Sci

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“…In a typical hepatic abscess, the most frequently isolated organisms include Escherichia coli, Klebsiella pneumoniae, Streptococcus viridans, Staphylococcus aureus, and rarely Clostridia spp. [11]. The mainstays of antibiotic treatment include cephalosporin, aminopenicillin, antipseudomonal penicillin, carbapenem, fluoroquinolone, aminoglycoside, and metronidazole [6].…”

Section: Discussionmentioning

confidence: 99%

“…The mainstays of antibiotic treatment include cephalosporin, aminopenicillin, antipseudomonal penicillin, carbapenem, fluoroquinolone, aminoglycoside, and metronidazole [6]. If size of the abscess is more than 2 cm, antibiotic treatment alone is reported to be insufficient [11] treatment results in lower rates of treatment failure in multiloculated abscesses, which are larger than 5 cm in size [12].…”

Section: Discussionmentioning

confidence: 99%

Pyogenic liver abscess as an extra-intestinal manifestation of pediatric Crohn’s disease

Bae,

Kim,

Kim

et al. 2023

Precis Future Med

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Crohn’s disease (CD) is a type of inflammatory bowel disease (IBD) characterized by chronic granulomatous inflammation of any part of the body, primarily the gastrointestinal (GI) tract, and is increasing in incidence worldwide. As CD is a systemic disease, the features of CD typically manifest in the GI tract; however, a variety of extra-intestinal manifestations, such as the involvement of joints, skin, and eyes may also occur. Although pyogenic liver abscess itself is rare in the general population (approximately 3–5 per 100,000 hospital admissions), it is also an unusual and rare presentation in pediatric CD patients. In this report, we present a case of pyogenic liver abscess in a 7-year-old female CD patient and discuss the clinical features, laboratory findings, imaging studies, and pathologic report of liver biopsy.

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“…БК может возникнуть в любом возрасте, хотя чаще дебют заболевания приходится на 15-30 лет. В современной литературе имеются описания единичных клинических случаев атипичного дебюта болезни Крона с гигантского абсцесса печени [2], изолированных легочных проявлений [3], офтальмологических проявлений в виде инфильтратов роговицы [4], в виде заболеваний гортани [5].…”

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Aphthous stomatitis as the debut of Crohn’s disease

Гаус

Ахмедов

Коршунов

2020

jour

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Crohn’s disease is an immune-mediated disease characterized by non-specific granulomatous transmural inflammation with segmental damage to any part of the gastrointestinal tract with the formation of extraintestinal and systemic complications. Clinical observation of patient I., 23 years old, a student who was sent for consultation to a gastroenterologist in the direction of a dentist, is presented. Active examination of the gastrointestinal tract during the inspection did not show any complaints. He considers himself ill for 6 months, when he first complained of pain in the neck, sore throat, and body temperature rise to 37.4–37.5 °C, mostly in the evening. Were treated by an otolaryngologist and a dentist without significant effect. In this connection, a biopsy of the ulcerative defect of the left retromolar region was performed, revealing noncaseating granulomatous inflammation. A follow-up examination by a gastroenterologist with colonoscopy and biopsy made it possible to establish Crohn’s disease as the true cause of aphthous stomatitis.

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A Rare Case of Crohn’s Disease Manifesting as a Large Liver Abscess

Cited by 4 publications

References 8 publications

Hepatic abscess in inflammatory bowel disease: A systematic scoping review of an overlooked entity

Hepatic abscess in inflammatory bowel disease: A systematic scoping review of an overlooked entity

Pyogenic liver abscess as an extra-intestinal manifestation of pediatric Crohn’s disease

Aphthous stomatitis as the debut of Crohn’s disease

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