A rare case of Corynebacterium riegelii urosepsis: Role of the MALDI-TOF mass spectrometry in the identification of emerging pathogens

Pichon, Maud; Micaëlo, Maïté; Longuet, Pascal; Plantefève, Gaëtan; Abderrahmane, Malika; Wifaq, Bouchra; Menn, Anne-Marie

doi:10.1016/j.medmal.2019.06.005

Cited by 2 publications

(1 citation statement)

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“…By creating a specific reference urine database called Urinf, 90% of 500 samples were accurately diagnosed using MALDI-ToF ( 31 ). MALDI-ToF-MS was used to successfully identify Corynebacterium rigelii , a pathogen that causes urinary tract infections, from a case of urosepsis in a 67-year-old female patient ( 32 ). The urine-short incubation MALDI-TOF (U-si-MALDI-ToF) method was created mainly for the detection of E. coli , a bacteria that causes urinary tract infections.…”

Section: Role Of Proteomics In Identifying Pathogensmentioning

confidence: 99%

Proteomics approaches: A review regarding an importance of proteome analyses in understanding the pathogens and diseases

Zubair

Wang

et al. 2022

Front. Vet. Sci.

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Proteomics is playing an increasingly important role in identifying pathogens, emerging and re-emerging infectious agents, understanding pathogenesis, and diagnosis of diseases. Recently, more advanced and sophisticated proteomics technologies have transformed disease diagnostics and vaccines development. The detection of pathogens is made possible by more accurate and time-constrained technologies, resulting in an early diagnosis. More detailed and comprehensive information regarding the proteome of any noxious agent is made possible by combining mass spectrometry with various gel-based or short-gun proteomics approaches recently. MALDI-ToF has been proved quite useful in identifying and distinguishing bacterial pathogens. Other quantitative approaches are doing their best to investigate bacterial virulent factors, diagnostic markers and vaccine candidates. Proteomics is also helping in the identification of secreted proteins and their virulence-related functions. This review aims to highlight the role of cutting-edge proteomics approaches in better understanding the functional genomics of pathogens. This also underlines the limitations of proteomics in bacterial secretome research.

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Section: Role Of Proteomics In Identifying Pathogensmentioning

confidence: 99%