A rare case of cancer-to-cancer metastasis: breast cancer to renal cell cancer

Abstract

SummaryBackgroundCancer-to-cancer metastasis is very rare with less than 50 cases described in literature. This article reports a case of breast cancer with synchronous metastasis to clear cell renal cell cancer.Case descriptionA 79-year-old woman was diagnosed with a bilateral breast carcinoma. Sonographic staging investigation of the abdomen revealed a 6 cm wide expansion of the right kidney. Bilateral mastectomy and nephrectomy of the right kidney was performed. The histology revealed a clear cell renal cell carcinoma and in the center of the tumor a 0.5 cm metastasis of the breast cancer. The patient’s comorbidities and performance status precluded chemotherapy und she received palliative radiotherapy, targeted monoclonal antibody therapy and antihormonal treatment.ConclusionsEven if cancer-to-cancer metastasis is a very rare phenomenon, the simultaneous or consecutive finding of a renal tumor in women with breast cancer should be carefully evaluated.

Incidentaloma on Staging CT Revealed to Be Breast to Renal Tumour-to-Tumour Metastasis

“…To our knowledge, there have been only 10 other reports of invasive ductal carcinoma of the breast metastasising to an RCC, two of which were diagnosed on autopsy [ 14 , 15 ]. Interestingly, from our review of the literature, this is the first case to report the TTM before any other radiologically detected metastases, besides ipsilateral axillary lymph nodes.…”

F-FDG18PET/CT incidental detection of tumor-to-tumor metastasis in patients investigated for squamous cell lung cancer

“…In fact, most cases found in living patients with TTM, have been diagnosed incidentally in nephrectomy specimen for renal cancer, or more rarely, on renal biopsy. Occasionally, some cases of TTM were discovered during autopsy [ 1 , 2 , 8 , 9 ].…”

“…The latter can be focal and small, requiring a wide sampling of the biopsied specimen, including all the heterogeneous areas. All that for the sake of avoiding any misleading of these metastatic foci, given their importance in making the accurate diagnosis, and for all the subsequent possible prognostic and therapeutic implications [ 1 , 9 , 12 ]. IHC is an essential part of the histological diagnosis of these cases and should be performed systematically as soon as the pathologist detects 2 different tissue components.…”

Case report: Robot-assisted partial nephrectomy of renal metastasis from breast cancer with Da Vinci Xi

“…От извършения литературен обзор се установиха десет описани клинични случая на единична метастаза в бъбрек от карцином на гърда (13). При различните случаи хормоналният статус е вариабилен (13). При повечето пациенти е из- (13).…”