A Rare Case of Arterial and Venous Thromboembolism in a Patient With Severe Clostridium difficile Infection

Kumar, Aneesh; Ghazanfar, Haider; Davidson, Joshua

doi:10.7759/cureus.16103

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…The authors reported the case of an 82-year-old woman admitted to the emergency area for septic shock secondary to CDI. During the hospitalization, bilateral lower extremity venous thrombosis, pulmonary embolism, multifocal thromboembolic brain infarctions, and acute arterial thromboembolic occlusion of the right upper and lower extremities were detected [72].…”

Section: Incidence Of Vte In Hospitalized Patients With CDImentioning

confidence: 99%

Clostridium difficile Induced Inflammasome Activation and Coagulation Derangements

et al. 2022

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C. difficile enterocolitis (CDAC) is the most common hospital infection, burdened by an increased incidence of coagulation-related complications such as deep vein thrombosis (DVT) and disseminated intravascular coagulation (DIC) as well as a significant sepsis-related mortality. In this review, we analyzed the available data concerning the correlation between coagulation complications related to C. difficile infection (CDI) and inflammasome activation, in particular the pyrin-dependent one. The little but solid available preclinical and clinical evidence shows that inflammasome activation increases the risk of venous thromboembolism (VTE). As proof of this, it has been observed that in vitro inhibition of the molecules (e.g., tissue factor) mainly involved in coagulation activation could block the process. In vivo studies show that it could be possible to reduce the incidence of complications associated with C. difficile infection (CDI) and mortality due to a state of hypercoagulability. A personalized therapeutic approach to reduce the inflammatory activity and prevent thromboembolic complications could be preliminarily defined to reduce mortality.

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Section: Incidence Of Vte In Hospitalized Patients With CDImentioning

confidence: 99%

Clostridium difficile Induced Inflammasome Activation and Coagulation Derangements

et al. 2022

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“…The study found that antidepressant drug use was not correlated with risk of infection; instead, GABAergic drug use (benzodiazepines in particular) was associated (Lalani et al, 2020 ). C. difficile also been shown to result in severe brain infarction and thromboembolism (Kumar et al, 2021 ), but very few information is currently available and further investigations are needed to deeper study the correlation.…”

Section: Microbiota-targeted Strategies Targeting C Diffici...mentioning

confidence: 99%

Clostridioides difficile and neurological disorders: New perspectives

2022

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Despite brain physiological functions or pathological dysfunctions relying on the activity of neuronal/non-neuronal populations, over the last decades a plethora of evidence unraveled the essential contribution of the microbial populations living and residing within the gut, called gut microbiota. The gut microbiota plays a role in brain (dys)functions, and it will become a promising valuable therapeutic target for several brain pathologies. In the present mini-review, after a brief overview of the role of gut microbiota in normal brain physiology and pathology, we focus on the role of the bacterium Clostridioides difficile, a pathogen responsible for recurrent and refractory infections, in people with neurological diseases, summarizing recent correlative and causative evidence in the scientific literature and highlighting the potential of microbiota-based strategies targeting this pathogen to ameliorate not only gastrointestinal but also the neurological symptoms.

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A Rare Case of Arterial and Venous Thromboembolism in a Patient With Severe Clostridium difficile Infection

Cited by 2 publications

References 11 publications

Clostridium difficile Induced Inflammasome Activation and Coagulation Derangements

Clostridium difficile Induced Inflammasome Activation and Coagulation Derangements

Clostridioides difficile and neurological disorders: New perspectives

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