A Rare Case of Ankyloblepharon Filiforme Adnatum

Abstract

Ankyloblepharon Filiforme Adnatum (AFA) is an extremely rare congenital anamoly occuring due to failure of separation of eyelids during fetal development. Despite its dramatic presentation, the treatment is bedside release of the adhesions and thus restoring vision and cosmesis. The hesitation on the part of treating physician or pediatrician can lead the child to amblyopia, and we report this case to add to the exisiting literature for a better understanding of the disease.

Management of an Isolated Type I Ankyloblepharon Filiforme Adnatum (AFA) with Coloboma of the Upper Eyelid in a Newborn

“…[7] AFA is usually a solitary malformation of sporadic occurrence but can occur in an autosomal dominant pattern associated with cleft lip and palate in most familial cases. [12], [13] Recent research [10], [11] demonstrates that AFA can occur both alone and in conjunction with other ocular anomalies, trisomy or other multisystemic syndromes, including Hay-Wells syndrome [13] , also known as ankyloblepharon ectodermal defects cleft lip or palate (AEC) syndrome. [11] A large number of congenital malformations and anomalies (ectodermal defects, cleft lip or palate, and limb anomalies) are associated with AFA.…”

“…[11] A large number of congenital malformations and anomalies (ectodermal defects, cleft lip or palate, and limb anomalies) are associated with AFA. [12] The abnormal embryological development of syndrome; and Rapp-Hodge-kin syndrome (RHS). [14] All of these uncommon multisystemic illnesses are caused by mutations in the p63 gene, a transcription factor connected to the tumor suppressors p53 and p73.…”