A rare case of adrenal ganglioneuroblastoma-intermixed in an adult and a review of literature

Vassallo, Lorenzo; Fasciano, Mirella; Baralis, I.; Pellegrino, Luca; Fortunato, M.; Orcioni, Giulio Fraternali; Sorrentino, Stefania

doi:10.1016/j.radcr.2021.06.005

Cited by 7 publications

(25 citation statements)

References 26 publications

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“…Our results from the literature review, including patient age, treatment type, and symptoms, are compatible with the conclusions made from previous literature reviews conducted on the adult onset of adrenal GNB cases [1,9,12]. However, these literature reviews concluded that adrenal GNBs of adult-onset were seen in males with a greater magnitude than our findings.…”

Section: Reviewsupporting

confidence: 91%

Adrenal Ganglioneuroblastoma of Adult Onset: Literature Review

Stevens¹,

Malone²,

Dufrene³

et al. 2023

Cureus

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Ganglioneuroblastomas (GNBs) are a rare subtype of neoplastic tumors that arise from the autonomic nervous system and contain both mature gangliocytes and immature neuroblasts. The primary age group affected by GNBs is the pediatric population, with less than 50 cases of adult GNBs existing in the literature. To the authors' best knowledge, only 21 cases of GNBs arising in the adrenal glands of adults have been reported. Herein we present a literature review examining the symptoms, treatment type, age, and sex of adults, and the presence of tumor metastases and calcification from the 21 cases reported in the literature.

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Section: Reviewsupporting

confidence: 91%

Adrenal Ganglioneuroblastoma of Adult Onset: Literature Review

Stevens¹,

Malone²,

Dufrene³

et al. 2023

Cureus

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“…It usually occurs in pediatric patients aged <10 years, particularly between the ages of 1 and 2 years ( 3 ). By contrast, GNB is rare in adolescents and adults, with previous studies reporting <50 cases in adults ( 4 ). The most common site of origin for GNB is the adrenal medulla (~35%), followed by the retroperitoneum, brain and mediastinum, with tissues such as the orbit and parotid gland also reportedly involved ( 5 – 13 ).…”

Section: Introductionmentioning

confidence: 81%

Retroperitoneal ganglioneuroblastoma with postoperative stress ulcer perforation in an adolescent: A case report and review of the literature

et al. 2022

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Ganglioneuroblastoma (GNB) is a condition belonging to the neuroblastoma family. It is a transitional tumor consisting of a mixture of mature ganglioneuromas and malignant neuroblastomas. Its biological behavior is intermediate between benign and malignant, with a risk of recurrence and metastasis. It usually occurs in pediatric patients aged <10 years, particularly between the ages of 1 and 2 years, but may also occur in adolescents or adults. The present study reported on the clinical management of a case of postoperative stress ulcer with perforation in a 17-year-old female patient with retroperitoneal GNB and provided a review of the literature on retroperitoneal GNB in adolescents and adults.

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“…According to a recent retrospective study, 48% of patients with abdominal NB and 29% of patients with abdominal GNB had metastatic disease ( 18 ). Thus, functional imaging like I 123 -MIBG-scan or FDG PET-CT, are essential in the assessment of NB and GNB to define the extent of disease at diagnosis and to follow the treatment response ( 21 , 22 ). Notably, it was shown that FDG can be useful when interpretation of MIBG is unclear ( 23 ).…”

Section: Discussionmentioning

confidence: 99%

“…Regarding treatment, the presented patient had surgery without chemotherapy or radiation therapy. In adults, due to rarity, there are no standardized guidelines or treatment protocols for NN ( 22 ). According to the three case reports mentioned above, the treatment of the GN and NB was surgical without adjuvant treatment.…”

Section: Discussionmentioning

confidence: 99%

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Neuroblastic Tumors of the Adrenal Gland in Elderly Patients: A Case Report and Review of the Literature

et al. 2022

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BackgroundNeuroblastic neoplasms (NN) include ganglioneuromas (GN), ganglioneuroblastomas (GNB), and neuroblastomas (NB). They generally arise in childhood from primitive sympathetic ganglion cells. Their incidence in adults, especially among elderly, is extremely low.Case PresentationThis is the case of a 74-year-old woman with history of abdominal pain, weakness and night sweating since several months. Blood pressure was normal. CT-scan showed a 10 cm left adrenal mass, without other pathologic findings. An open left-sided adrenalectomy was performed. Recovery was uneventful with hospital length of stay of 8 days. Based on morphological, immunohistochemical, and molecular features the diagnosis was a nodular GNB. A positron emission tomography (PET) performed 6 weeks after the resection did not show any residual tumor or distant metastases. The patient was followed-up with annual clinical and radiological exams.ConclusionThis case presentation, associated with a review of the literature, illustrates the importance to include NN in the preoperative differential diagnosis of adrenal tumors in adults and highlights the need for multidisciplinary patient work-up and management.

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A rare case of adrenal ganglioneuroblastoma-intermixed in an adult and a review of literature

Cited by 7 publications

References 26 publications

Adrenal Ganglioneuroblastoma of Adult Onset: Literature Review

Adrenal Ganglioneuroblastoma of Adult Onset: Literature Review

Retroperitoneal ganglioneuroblastoma with postoperative stress ulcer perforation in an adolescent: A case report and review of the literature

Neuroblastic Tumors of the Adrenal Gland in Elderly Patients: A Case Report and Review of the Literature

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