A Rare Case of a High-Grade Thymic Squamous Cell Carcinoma Presenting as Cardiac Tamponade

Rai, Maitreyee; Keogh, Alan

doi:10.7759/cureus.9366

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…1,9 Pericardial tamponade complicating thymoma is rare, with only a few published case reports over the years. 6,[10][11][12] Despite a higher yield of fluid cytology in malignant cases (50-80%), prior reports of thymoma invading pericardial space have shown nondiagnostic fluid analysis. 6,10 Video 2 Noncontrast, axial bright blood imaging showing large heterogenous intrapericardial mass extending superiorly to the arch and encasing the aorta; see also at https://youtu.be/pnJ-g_lxM0c.…”

Section: Discussionmentioning

confidence: 99%

Think Outside the Heart: An Unusual Cause of Large Hemopericardium

Basha,

Wessly,

Chamsi-Pasha

2023

Methodist DeBakey Cardiovascular Journal

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Pericardial effusions secondary to tumors are commonly metastatic, originating primarily from the lung, breast, and lymphomas. Pericardial tamponade is a rare oncological emergency warranting early identification and treatment. We describe a 66-year-old male found to have a large bloody pericardial effusion causing tamponade physiology, and multimodality imaging was consistent with intrapericardial malignancy with no identifiable primary source. He was subsequently diagnosed with type B3 thymoma after mediastinal resection.

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Section: Discussionmentioning

confidence: 99%

Think Outside the Heart: An Unusual Cause of Large Hemopericardium

Basha,

Wessly,

Chamsi-Pasha

2023

Methodist DeBakey Cardiovascular Journal

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“…Thymic carcinoma (TC) is a rare aggressive malignancy with poor prognosis. TC rarely causes cardiac tamponade; however, when it does, such cases have a particularly poor prognosis [1][2][3][4][5][6]. In fact, there are no reports of TC with cardiac tamponade surviving for 1 year.…”

Section: Introductionmentioning

confidence: 99%

Successful treatment with lenvatinib in a patient with thymic carcinoma presenting with cardiac tamponade: a case report and review of literature

et al. 2022

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Thymic carcinoma (TC) presenting with cardiac tamponade has a poor prognosis because of the difficulty in controlling malignant pericardial effusion using conventional chemotherapy. Lenvatinib, a multitargeted kinase inhibitor of vascular endothelial growth factor receptor and other kinases, has recently been proven effective against TC. As the inhibition of vascular endothelial growth factor signaling is effective in malignant pericardial effusion, lenvatinib may also be effective in TC presenting with cardiac tamponade. However, no reports have shown that lenvatinib is effective in such cases. Herein, we present a case of successful treatment with lenvatinib in a patient with TC presenting with cardiac tamponade. The present case suggests that lenvatinib should be considered an effective treatment option for such cases.

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A Rare Case of a High-Grade Thymic Squamous Cell Carcinoma Presenting as Cardiac Tamponade

Abstract: Rai et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Cited by 2 publications

References 8 publications

Think Outside the Heart: An Unusual Cause of Large Hemopericardium

Think Outside the Heart: An Unusual Cause of Large Hemopericardium

Successful treatment with lenvatinib in a patient with thymic carcinoma presenting with cardiac tamponade: a case report and review of literature

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