A Rare Case of a Synchronous Anaplastic Carcinoma Thyroid with Ductal Carcinoma Breast

Ghosh, Saptarshi; Rao, Pamidimukkala Bramhananda; Sarkar, Shreyasee; Kotne, Sivasankar; Turlapati, S. P. V.; Mishra, Anindita

doi:10.1155/2014/468159

Cited by 5 publications

(7 citation statements)

References 10 publications

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“…Dual malignancy was first reported by Billroth in 1889. [ 4 ] Recently, concern about the risk of developing 2 primary tumors synchronously has increased. Previous studies have mainly focused on possible increases in the incidence of contralateral breast carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…If papillary thyroid carcinoma and breast ductal carcinoma are detected synchronously, the breast ductal carcinoma should be resected upon the exclusion of medullary or anaplastic thyroid carcinoma because breast ductal carcinoma is more likely to present with distant metastasis and to have a poorer prognosis. [ 4 ]…”

Section: Discussionmentioning

confidence: 99%

“…The first report on this dual malignancy was written by Billroth in 1889. [ 4 ] According to the guidelines [ 5 , 6 ] , these 2 malignancies can be synchronous but should not be metachronous. Neither tumor should arise as a metastasis from the other nor the tumors should be separate from each other in terms of their microscopic and morphologic features, which means that they cannot have metastasized from another site.…”

Section: Introductionmentioning

confidence: 99%

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Synchronous papillary thyroid carcinoma and breast ductal carcinoma

Zhong

Lei²,

Jiang³

et al. 2017

Medicine

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Background:The incidences of both thyroid cancer and breast cancer have been rising in recent years; however, it is very rare to find a single person with both of these cancers. Only a few cases of synchronous thyroid and breast cancer have been published, and even fewer cases have been reported in older patients (>60 years).Case summary:The current study presents a case of synchronous papillary thyroid carcinoma and breast ductal carcinoma in an elderly patient. The patient first underwent a mastectomy and axillary lymphadenectomy in our department, followed by a total thyroidectomy and lymphadenectomy of the left lateral region of the neck 1 month later. Postoperative pathological examination identified invasive ductal carcinoma of the breast and papillary carcinoma of the thyroid. Over almost half a year of follow-up, the patient has exhibited no evidence of recurrence or metastasis, as demonstrated by careful ultrasound examinations. Herein, we not only report this case but also present a systematic review of the causes, diagnosis, and treatment of synchronous breast and thyroid cancer.Conclusion:Although synchronous primary tumors of the thyroid and breast are very rare, they remain a possibility; therefore, more attention should be paid to these cases.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Synchronous papillary thyroid carcinoma and breast ductal carcinoma

Zhong

Lei²,

Jiang³

et al. 2017

Medicine

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“…Dual malignancy, first reported by Billroth [1], is rarely associated to paraneoplastic syndromes (Table 1) [2][3][4][5]. The second malignancy can be synchronous or metachronous if detected within more than 6 months of the diagnosis of the first histologically different malignant tumor [1].…”

Section: Introductionmentioning

confidence: 99%

“…The second malignancy can be synchronous or metachronous if detected within more than 6 months of the diagnosis of the first histologically different malignant tumor [1]. Although dancing eye syndrome or opsoclonus-myoclonus-ataxia (OMA) is a classical central nervous system paraneoplastic syndrome [6], it has never been reported in patient with concurrent cancers.…”

Section: Introductionmentioning

confidence: 99%

Paraneoplastic opsoclonus-myoclonus-ataxia syndrome revealing dual malignancy

et al. 2016

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Risk Factors of Synchronous Breast and Thyroid Cancer: a Controlled Multicenter Study and Review of the Literature

Zervoudis¹,

Iatrakis²,

Markja³

et al. 2021

Mater Sociomed

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Background: Breast cancer (BC) is one of the most common cancers diagnosed in women in the United States. Thyroid cancer (TC) is also one of the fastest increasing cancer types in the United States, with most cases being papillary thyroid carcinomas. Objective: To identify possible risk factors for the synchronous or metachronous co-occurrence of breast and thyroid cancers. Methods: We carried out a study, which consisted of data from four gynecological clinics: two in Greece (Athens, Alexandroupolis, Ioannina) and one in Germany, collected from June 2017 to June 2020. The patients were divided into two groups: the first group consisted of 58 patients with breast cancer and a personal history of thyroid cancer. The second group (control group) included 50 patients with the same characteristics as to age, parity, type of pregnancy, treatment for sterility, polycystic ovaries, regularity of the menstrual cycle, breast density, BMI, family history of cancer, blood group rhesus and histological results of breast cancer. The data we collected were analyzed using version 20 of the SPSS statistical package. The Chi-square test was used for statistical analysis and a p-value<0.005 was considered statistically significant. Results: The only factors that seem to be related with the association of breast and thyroid cancer were: history of abortion and multiparity. Conclusion: In our study there is a higher chance of developing breast cancer after diagnosing thyroid cancer and vice versa. More than genetic mutations, a possible hormonal pathway of these two malignancies is possible. The hormonal change in women who had many children or abortions could be a risk factor to develop both cancers. More studies are necessary to confirm our findings.

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A Rare Case of a Synchronous Anaplastic Carcinoma Thyroid with Ductal Carcinoma Breast

Cited by 5 publications

References 10 publications

Synchronous papillary thyroid carcinoma and breast ductal carcinoma

Synchronous papillary thyroid carcinoma and breast ductal carcinoma

Paraneoplastic opsoclonus-myoclonus-ataxia syndrome revealing dual malignancy

Risk Factors of Synchronous Breast and Thyroid Cancer: a Controlled Multicenter Study and Review of the Literature

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