A Rare Case of a Large Primary Renal Neuroendocrine Tumour: A Case Report and Brief Review of Literature

Deacon, Matthew J; Harvey, Hannah; Shah, Chirag; Khan, Azhar

doi:10.7759/cureus.19743

Cited by 4 publications

(7 citation statements)

References 15 publications

(41 reference statements)

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“…Some reports on PRNTs have shown morphological and immunohistochemical features consistent with the hindgut neuroendocrine phenotype ( 12 ), suggesting metastases from an occult NET elsewhere in the body. The most popular hypothesis, the totipotent cell hypothesis, states that PRNTs arise from primitive stem cells capable of neuroendocrine differentiation ( 13 ). However, direct evidence for this hypothesis is currently lacking.…”

Section: Discussionmentioning

confidence: 99%

Rare renal well-differentiated neuroendocrine tumors: clinical and imaging characteristics in a series of three cases

Zeng,

Xu,

Wang

et al. 2024

Quant Imaging Med Surg

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Section: Discussionmentioning

confidence: 99%

Rare renal well-differentiated neuroendocrine tumors: clinical and imaging characteristics in a series of three cases

Zeng,

Xu,

Wang

et al. 2024

Quant Imaging Med Surg

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“…NETs can arise from any tissue or organ, even organs that do not normally have neuroendocrine cells [ 4 ]. Primary neuroendocrine tumors of the kidney compile less than 0.4% of all NETs [ 6 ]. Based on the review of renal NETs by Cleveland Clinic, horseshoe kidney (17.8%) and teratomas (14.3%) can be commonly found in patients with renal NETs.…”

Section: Discussionmentioning

confidence: 99%

“…However, in the literature, the occurrence of RCC with simultaneous urothelial carcinoma is rare, with around 50 cases reported total [ 3 ]. Even more seldom seen than either of the aforementioned malignancies in isolation are renal neuroendocrine tumors (NETs) which are exceedingly rare with only 100 described in the literature and an overall incidence of primary renal NETs being 0.13 per one million people [ 4 , 5 , 6 ]. Furthermore, primary neuroendocrine tumors of the kidney compile less than 0.4% of all NETs [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…Even more seldom seen than either of the aforementioned malignancies in isolation are renal neuroendocrine tumors (NETs) which are exceedingly rare with only 100 described in the literature and an overall incidence of primary renal NETs being 0.13 per one million people [ 4 , 5 , 6 ]. Furthermore, primary neuroendocrine tumors of the kidney compile less than 0.4% of all NETs [ 6 ]. Here, we present the case of a patient found to have renal neuroendocrine cancer, clear cell RCC, and high-grade urothelial cancer concurrently.…”

Section: Introductionmentioning

confidence: 99%

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Triple Threat: Three Primary Malignancies Simultaneously Involving Three Genitourinary Organs

Mitchell

Naili

Pillai

et al. 2023

Case Reports in Urology

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Statistically, the chance of having concurrent renal cell carcinoma (RCC), urothelial carcinoma of the bladder (UC), and a neuroendocrine tumor (NET) of the renal parenchyma is less than one in a trillion. Herein, we describe an unusual case of a 67-year-old female who presented with bilateral flank pain and severe gross hematuria. Cross-sectional imaging revealed two large heterogeneous, endophytic renal masses with a single enlarged paracaval lymph node. Diagnostic cystoscopy was performed for completion of gross hematuria evaluation and revealed a concurrent papillary bladder tumor. Percutaneous biopsies of bilateral renal masses revealed clear cell RCC involving the left kidney and well-differentiated NET involving the right kidney, and transurethral resection of the bladder tumor revealed high-grade nonmuscle invasive urothelial carcinoma. The patient elected to undergo bilateral nephroureterectomy, radical cystectomy, and retroperitoneal and pelvic lymphadenectomy. Final pathology confirmed the presence of three different malignancies: noninvasive high-grade papillary UC of the bladder (pTaN0), left renal clear cell RCC (pT2bN0), right renal well-differentiated NET, and a single paracaval lymph nodes positive for metastatic NET (pT2aN1).

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“…WDNETs have a low degree of malignancy, slow growth and optimal prognosis. Surgical resection is the preferred approach for patients without metastases; however in the presence of metastasis, either pre-or post-operatively, systemic therapies for renal NETs have been directed by the treatment of non-renal NETs (24). Romero et al (10) indicated that ~50% of patients with WDNETs undergoing radical nephrectomy demonstrated no recurrence or metastasis following an average follow-up time of 43 months.…”

Section: Discussionmentioning

confidence: 99%

Well‑differentiated neuroendocrine tumor of the right kidney: A case report

Yang

Tang

et al. 2023

Oncol Lett

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Neuroendocrine tumors (NETs) are tumors originating from neuroendocrine cells and peptidergic neurons. Primary renal well-differentiated NETs (WDNETs) are rare and only sporadic cases have been reported worldwide. In November 2021, a 45-year-old female patient was admitted to The Affiliated Hospital of Zunyi Medical University (Zunyi, China) with right-sided lumbago. Abdominal computed tomography revealed a 44x34x70-mm mass in the right kidney. Following a complete examination, a laparoscopic partial nephrectomy of the right kidney was performed under general anesthesia. The postoperative pathology indicated a well-differentiated NET of the right kidney. There was no tumor recurrence or metastasis during the 1-year follow-up period. WDNETs are rare, their clinical and imaging findings are not specific, and their diagnosis depends on immunohistochemical analysis. The degree of malignancy is low and the prognosis is positive. Surgical resection is often the first choice, and long-term follow-up is required.

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A Rare Case of a Large Primary Renal Neuroendocrine Tumour: A Case Report and Brief Review of Literature

Cited by 4 publications

References 15 publications

Rare renal well-differentiated neuroendocrine tumors: clinical and imaging characteristics in a series of three cases

Rare renal well-differentiated neuroendocrine tumors: clinical and imaging characteristics in a series of three cases

Triple Threat: Three Primary Malignancies Simultaneously Involving Three Genitourinary Organs

Well‑differentiated neuroendocrine tumor of the right kidney: A case report

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