A Rare Case of a Gastrointestinal Stromal Tumor (GIST) Presenting as a Perforated Meckel’s Diverticulum

Omerza, Christopher R.; Bouman, Andrea Kay; Bulinski, Patrick

doi:10.1007/s12029-016-9803-y

Cited by 4 publications

(2 citation statements)

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“…All patient data were combined to create this report. There have been 18 cases of GIST in perforated Meckel's diverticulum, as shown in Table 1 [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]. No recurrences were reported.…”

Section: Discussionmentioning

confidence: 99%

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Gastrointestinal stromal tumor in perforated Meckel’s diverticulum: a case report and literature review

et al. 2020

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Introduction Gastrointestinal stromal tumor (GIST) is rare neoplasms of the gastrointestinal tract associated with high rates of malignant transformation. GIST has been found largely in the stomach, small bowel, colon and rectum, and esophagus, but about 5% are found in other locations. We herein report a 56-year-old woman with a GIST in perforated Meckel's diverticulum. After encountering this patient, a review of the literature found reports of 18 similar patients. Case presentation A 56-year-old woman diagnosed with galactosialidosis (β-galactosidase-neuraminidase deficiency) presented with vomiting. On contrast-enhanced computed tomography, peritonitis due to perforation of the intestine was diagnosed based on the free air and dilated loop of the small bowel. Laparotomy revealed perforation of Meckel’s diverticulitis located 50 cm from the ileocecal valve. Partial resection of the ileum, including the diverticulum, and end-to-end anastomosis of the small intestine were performed. Regarding the pathological findings, the edge of the diverticulum wall consisted of a solid mass measuring 1.0 cm in size, and the tumor cells were spindle-shaped with 1 mitosis present per 50 high-power fields. The diagnosis was established as GIST of the Meckel's diverticulum. The postoperative period was uneventful. Follow-up at two years revealed no evidence of recurrence. Conclusion GIST in perforated Meckel's diverticulum is very rare. The potential for the coexistence of GIST or other tumor should be considered in the treatment of perforated Meckel's diverticulum.

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Section: Discussionmentioning

confidence: 99%

“…In the review, almost all of the patients required small bowel resection. Since 2013, seven patients underwent imatinib chemotherapy after their operation [19][20][21][22][23][24][25]. The tumors ranged in longitudinal length from 1 to 14 cm.…”

Section: Discussionmentioning

confidence: 99%

Gastrointestinal stromal tumor in perforated Meckel’s diverticulum: a case report and literature review

et al. 2020

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Perforated Gastrointestinal Stromal Tumor of the Meckel’s Diverticulum: a Case Report and Review of Literature

2016

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Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the GI tract, they have a wide spectrum of clinical manifestations, and a small proportion of them present as an acute abdomen due to obstruction, perforation, or hemoperitoneum. We present a case of a perforated GIST of the Meckel's diverticulum and review the current literature on perforated GISTs. We ran a search on Pubmed and Google Scholar with the following terms Bperforated GIST,^Bperforated Meckel's diverticulum,B GIST with peritonitis,^and BGIST in Meckel's diverticulum.^After selecting the relevant articles, we tabulated our results and analyzed the data. Out of the 45 cases, 32 (71.1 %) were male and 13 (28.8 %) were female. Out of the 45 reported cases, 41 (91.1 %) were from the small intestine, 2 (4.44 %) cases from the stomach, and 2 (4.44 %) from the small bowel. In 15 (33.33 %) cases, the site of perforation was the Meckel's diverticulum (MD). Forty-year-old male, presented with features of peritonitis localized to the right iliac fossa, was diagnosed as acute appendicitis and subjected to a diagnostic laparoscopy. Intraoperatively, a perforated Meckel's diverticulum was found, which on histopathological examination contained a low-grade GIST. Our literature search revealed that in reported cases of perforated GISTs, there is a slight male preponderance. Small bowel appears to be the most common site for a perforated GIST, and a significant proportion (30.23 %) arise from the Meckel's diverticulum. And most importantly, the commonest tumor to cause perforation of a Meckel's diverticulum is a GIST.

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GIST in perforated Meckel's diverticulum

Zidan,

Hassan,

Sabry

et al. 2023

Surgery Open Digestive Advance

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A Rare Case of a Gastrointestinal Stromal Tumor (GIST) Presenting as a Perforated Meckel’s Diverticulum

Cited by 4 publications

References 23 publications

Gastrointestinal stromal tumor in perforated Meckel’s diverticulum: a case report and literature review

Gastrointestinal stromal tumor in perforated Meckel’s diverticulum: a case report and literature review

Perforated Gastrointestinal Stromal Tumor of the Meckel’s Diverticulum: a Case Report and Review of Literature

GIST in perforated Meckel's diverticulum

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