A Rare Case of a Signet Ring Cell Carcinoma of the Colon Mimicking a Juvenile Polyp

Kang, Sun Hyung; Chung, Woosuk; Hyun, Chang Lim; Moon, Hee Seok; Lee, Eaum Seok; Kim, Seok Hyun; Sung, Jae Kyu; Lee, Byung Seok; Kim, Jeong Il

doi:10.5009/gnl.2012.6.1.129

Cited by 13 publications

(14 citation statements)

References 4 publications

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“…Adenomatous or malignant changes have been observed in subjects with JPS and also in those with sporadic JPs (16,17). In the present study, no malignant changes were detected; nonetheless, EC is able to detect malignant changes as it enables the assessment of nuclei in real time.…”

Section: Discussionmentioning

confidence: 56%

Magnifying chromoendoscopic and endocytoscopic findings of juvenile polyps in the colon and rectum

et al. 2015

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Abstract. A precise endoscopic diagnosis is necessary for endoscopic therapy for neoplastic and non-neoplastic lesions, including juvenile polyps (JPs). Therefore, the present study aimed to clarify the characteristic endoscopic findings of JPs. A total of 154 JPs were evaluated by magnifying chromoendoscopy, 20 of which were also assessed by endocytoscopy using an ultra-high magnification endoscope. Endoscopic images were evaluated in terms of gross appearance, color, pit pattern, surface inflammatory changes and vascularity of polyps. Endocytoscopic images were evaluated with regard to the morphology of glandular cavities, nuclei of glandular cells and interstitial features. Reddish surfaces (98.1%), surface erosion (92.2%), open pits (90.3%) and low pit density (90.3%) were observed in the majority of JPs by chromoendoscopy. In addition, dilated ductal openings surrounded by normal glandular cells (100%), greater distances between gland basal layers (100%) and interstitial infiltration by inflammatory cells (100%) were observed in all JPs examined by endocytoscopy. These findings indicate that there is a tetralogy of magnifying chromoendoscopic findings characteristic of JPs: Reddish surfaces, surface erosion, open pits and low pit density. There is also a triad of endocytoscopic findings characteristic of JPs, namely dilated ductal openings surrounded by normal glandular cells, greater distances between gland basal layers, and interstitial infiltration by inflammatory cells. The aforementioned magnifying chromoendoscopic and endocytoscopic characteristics of JPs may be useful factors for diagnosing JPs.

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Section: Discussionmentioning

confidence: 56%

Magnifying chromoendoscopic and endocytoscopic findings of juvenile polyps in the colon and rectum

et al. 2015

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“…The vast majority of signet ring cell carcinoma (SRCC) arise in the stomach. Other less common locations of this tumor include the gallbladder, pancreas, colon, rectum, bladder, and breast [10, 11]. Hence, it is important to rule out a stomach origin of tumor via imaging and biopsies.…”

Section: Discussionmentioning

confidence: 99%

Signet Ring Cell Carcinoma of the Colon in Young Adults: A Case Report and Literature Review

Farraj

Sabbagh

Aridi

et al. 2019

Case Reports in Oncological Medicine

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Colorectal cancer (CRC), one of the leading causes of cancer-related deaths, presents with challenging features related to its diagnosis and management. The incidence of CRC in the adolescent and young adult (AYA) population has increased over the past couple of decades despite the decline in the overall occurrence of CRC in the general population. Signet ring cell carcinoma is one of the rare histopathologic subtypes of CRC; however, it is more prevalent in AYA patients than in older adults and presents with unconventional histologic characteristics, a distinct clinical behavior, and a poor prognosis. We report a case of a primary signet ring cell adenocarcinoma of the ascending colon in a 19-year-old male who presented with unusual signs and symptoms and was diagnosed with stage IVA (T4a N0 M1, with peritoneal seeding). The unusual presentation and location of the tumor in this case warrant further investigation.

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“…In mucinous AC (MAC), >50% of the lesion is extracellular mucin, and in SRCC, >50% of the tumor is signet ring cells with prominent intracytoplasmic mucin [3]. Almost 96% of SRCC originate in the stomach and the rest in the colon, rectum, pancreas, urinary bladder, and breast [4]. SRCC constitutes 1.1% of colorectal cancers [5].…”

Section: Discussionmentioning

confidence: 99%

Anorectal Cancer with Bone Marrow and Leptomeningeal Metastases

Zeeneldin

Al-Dhaibani

Saleh

et al. 2018

Case Reports in Oncological Medicine

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This is an interesting case of anorectal signet ring carcinoma with first presentation of an early stage disease, showing the aggressive disease and the undetectable behavior of this type of histology which can mislead diagnosis. Brain/CNS metastasis from colorectal cancer (CRC) is rare occurring in 3% of cases, and leptomeningeal carcinomatosis (LMC) is extremely rare in CRC (<0.02%). Symptoms and signs of LMC are pleomorphic and may be localized to three compartments: cerebral hemispheres, cranial nerves, and spinal cords and roots. Treatment of metastatic rectal cancer has been improving over the last few years with a lot of changes toward longer survival and improvement in quality of life and to change the disease into a chronic condition. However, in our case, the overall survival from the onset of LMC was 3 weeks only. Revising the evidence in the treatment of signet ring histology of rectal cancer, there is no specific treatment recommendation that is for this histology and for such very aggressive behavior which could be considered as a separate entity to the classic adenocarcinoma histology.

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A Rare Case of a Signet Ring Cell Carcinoma of the Colon Mimicking a Juvenile Polyp

Cited by 13 publications

References 4 publications

Magnifying chromoendoscopic and endocytoscopic findings of juvenile polyps in the colon and rectum

Magnifying chromoendoscopic and endocytoscopic findings of juvenile polyps in the colon and rectum

Signet Ring Cell Carcinoma of the Colon in Young Adults: A Case Report and Literature Review

Anorectal Cancer with Bone Marrow and Leptomeningeal Metastases

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