A rare case describing catastrophic destruction of the whole skeleton caused by severe hyperparathyroidism

Abstract

SUMMARYOsteitis fibrosa cystica is a skeletal disorder seen in advanced stages of persistent hyperparathyroidism. Although the measurement of serum Ca and intactparathormone levels provides early diagnosis and decreases the incidence of radiographic bone involvement, progressive major bone lesions may still be seen in developing countries even in the modern era. We aimed to share, by writing up this report, our astonishment after observing how the skeletal system can be ruined by persistent hyperparathyroidism. BACKGROUND

Sagliker syndrome in a patient with end-stage renal disease with secondary hyperparathyroidism

“…5 Brown tumors, a result of parathyroid hormone-driven osteoclastic activity with sclerosis causing abnormal bone remodeling, can be seen on imaging but need to be confirmed with biopsy. 6 Neurologic manifestations, hearing difficulty, and depression are other frequent symptoms. 3 The universal acceptance of this syndrome is still debated, because many characteristics are extreme manifestations of uncontrolled secondary hyperparathyroidism.…”