A rare cardiac inflammatory myofibroblastic tumor involving aortic valve

Luo, Wei; Teng, Peng; Ni, Yiming

doi:10.1186/s13019-017-0577-5

Cited by 10 publications

(4 citation statements)

References 6 publications

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“…They are infiltrated by myofibroblasts and inflammatory cells such as lymphocyte and plasmacytes. [ 1 ] In 2002, WHO officially designated the IMT name and defined these tumors as intermediate, occasionally metastatic and locally recurrent tumors. IMTs can develop in various tissue types at all ages, with the most common sites of localization including lung, liver, mesentery, omentum, and peritoneum.…”

Section: Introductionmentioning

confidence: 99%

Imaging findings of inflammatory myofibroblastic tumor in breast

Mao¹,

Liu²,

Du³

et al. 2018

Medicine

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Rationale:Inflammatory myofibroblastic tumors (IMTs), particularly breast IMTs, are rare neoplastic lesions typically associated with a favorable prognosis. Breast IMTs are easily misdiagnosed as other types of malignant lesions, and therefore there is a significant unmet need for a better preoperational differential diagnosis based on imaging manifestations. Here, we report the imaging findings of a breast IMT and compare our findings with previously published features of breast IMTs.Patient concerns:The patient, a 43-year-old female, reported the presence of a palpable lump within her left breast. An ultrasound examination revealed an irregular hypoechoic mass with unclear boundaries. Mammography demonstrated a mass of heterogeneous and striped density with granular calcification. Magnetic resonance image (MRI) inspection displayed an irregular tissue lump with an undistinguishable boundary and a further dynamic contrast-enhanced MRI disclosed an associated efflux change.Diagnoses:Breast inflammatory myofibroblastic tumors.Interventions:Breast needle biopsy and mammary resection were performed. Pathological staining of the bulk resected tumor after preoperative preparation revealed that the tumor-like tissue was enriched for spindle cells arranged in fascicular clusters. Histopathological diagnosis and immunohistochemistry confirmed the mass as being a breast IMT.Outcomes:No metastatic recurrence was found during 6-month or 1-year follow-ups.Lessons:Breast IMTs commonly develop in elderly women with atypical imaging features. They are primarily composed of lobular soft tissues infiltrated with an abundant focal blood supply and granular calcification. Development of breast IMTs is closely related to trauma. A preliminary diagnosis of such masses can be made based on combined manifestations of both clinical and imaging features, while a final confirmation still requires pathological staining. Imaging examinations are of value for such tumors to define the lesion edges and their associations with adjacent tissues.

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Section: Introductionmentioning

confidence: 99%

Imaging findings of inflammatory myofibroblastic tumor in breast

Mao¹,

Liu²,

Du³

et al. 2018

Medicine

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“…[4,7,8] After partial or complete resection of the tumor, the clinical outcomes appear to be satisfactory. [9,10] In the current case, although the mass was located in the interventricular septum, the rhythm of the heart was normal suggesting the conduction system was not involved. However, IMT is currently regarded as a neoplasm of intermediate biologic potential, with a 2% risk of metastasis and a 25% of recurrence rate.…”

Section: Discussionmentioning

confidence: 54%

Cardiac inflammatory myofibroblastic tumor in interventricular septum

et al. 2018

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Rationale:Cardiac inflammatory myofibroblastic tumor (IMT) is a rare primary cardiac tumor which is currently considered as a low-grade neoplasm. The tumor has a predilection in infants and adolescents and primarily occurs as an endocardial-based cavitary mass. However, cardiac IMT that only involves the interventricular septum in middle-aged adults is extremely rarely reported. Considering its infrequency, we report a rare clinical case, with the aim of sharing our experience during the diagnostic procedures.Patient concerns:A 45-year-old, previously healthy female, with no medical history was admitted to the outpatient clinic due to the identification of an abnormal radiographic finding during a routine health examination.Diagnosis:Transthoracic echocardiography (TTE) revealed a 3.5 cm × 4.0 cm × 4.5 cm heterogeneous mass in the interventricular septum. Color Doppler echocardiography detected sparse blood flow signals inside the mass. Magnetic resonance imaging (MRI) confirmed a hyperintense T2-weighted, isointense T1-weighted mass. Three-dimensional (3D) TTE demonstrated a spherical mass in the middle part of the interventricular septum. Postoperative histopathological examinations revealed a mesenchymal tumor composed of scattered spindle myofibroblasts with a myxoid atypia, associated with infiltration of lymphocytes and plasma cells.Interventions:Complete tumor resection was successfully performed via median sternotomy under general anesthesia.Outcomes:After surgery, the patient recovered successfully. The patient was in good general health without any clinical symptoms. The echocardiographic examination at the 12-month follow-up period revealed normal function of the heart, and there was no evidence of tumor recurrence.Lessons:To our knowledge, cardiac IMT only the involving interventricular septum in a middle-aged adult has never been previously reported before. Echocardiography plays a critical role in establishing the primary diagnosis of cardiac IMT and evaluating regular follow-up examinations. Complete surgical resection of the mass is considered the first-line treatment despite the absence of symptoms.

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“…Several studies have reported the onset of IMT in various somatic soft tissues. As described in this report, an IMT originating from the aorta is extremely rare, although less than 50 cardiac IMTs have been reported thus far [3].…”

Section: Discussionmentioning

confidence: 66%

Inflammatory myofibroblastic tumor arising from the ascending aorta mimicking a thymoma

Yun

Song

et al. 2019

Gen Thorac Cardiovasc Surg

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An inflammatory myofibroblastic tumor originating from the aorta is extremely rare. Here, we report a case involving a 41-year-old female patient with an aortic inflammatory myofibroblastic tumor. Although preoperative imaging showed a mediastinal mass indicative of invasive thymoma, surgical findings revealed that this mass originated from the aorta. The patient underwent partial resection of the aorta, including the mass with patch angioplasty. Based on the postoperative histological findings, the patient was diagnosed with an aortic inflammatory myofibroblastic tumor and is currently under outpatient follow-up.

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A rare cardiac inflammatory myofibroblastic tumor involving aortic valve

Cited by 10 publications

References 6 publications

Imaging findings of inflammatory myofibroblastic tumor in breast

Imaging findings of inflammatory myofibroblastic tumor in breast

Cardiac inflammatory myofibroblastic tumor in interventricular septum

Inflammatory myofibroblastic tumor arising from the ascending aorta mimicking a thymoma

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