A rare but severe complication of filgrastim in a healthy donor: Splenic rupture

Collection of peripheral blood progenitor cells on Day 4 is feasible and effective while reducing granulocyte–colony‐stimulating factor exposure to healthy donors

“…11 Severe adverse events, including splenic rupture and capillary leak syndrome, are rare. [12][13][14] Long-term side effects such as malignancies were not found to be associated with G-CSF stimulation. 6,9,10,15 Current surveillance data from allogeneic donors also demonstrated that serious adverse events are less frequently observed in PBPC donors compared to marrow donation.…”

“…These side effects appear to be dose dependent . Severe adverse events, including splenic rupture and capillary leak syndrome, are rare . Long‐term side effects such as malignancies were not found to be associated with G‐CSF stimulation .…”

Myeloid Growth Factors, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology

“…74 There have also been reports of rare cases of splenic rupture with G-CSF use, some of which were fatal. [90][91][92][93][94][95] These cases occurred in patients with underlying hematopoietic disorders, patients with solid tumors, and healthy donors of PBPC. The exact mechanism of G-CSF-induced splenic rupture is unknown, but is thought to involve intrasplenic accumulation of circulating granulocytes and myeloid precursors.…”

Peripheric Stem Cell Collection Practices At Childhood

“…Erişkinlerin aksine çocukluk döneminde kemik ağrısı sık görülmemektedir (1,13,14) . G-CSF'in çok ender olgu bildirimleri şeklinde olan ama ciddi yan etkileri dalak ruptürü, akciğer hasarı, rabdomyoliz ve otoimmüni-tedir (15)(16)(17)(18) . G-CSF tedavisinin uzun dönemde kanserle ilişkisi gösterilmemiştir (13) .…”