A rare association of congenital melanocytic nevus and lissencephaly in childhood seizure

Posterior quadrantic dysplasia with localized hemimegalencephaly in a patient with giant congenital melanocytic nevus: First case report

“…Previously, an association of GCMN with lissencephaly has been reported. 2 Shih et al reported a case of neurocutaneous melanocytosis with multiple intracranial anomalies including HME and a myxoid mesenchymal cerebral tumor. 3 Ahmed and colleagues described an infant presenting with GCMN in association with encephalocraniocutaneous lipomatosis who had HME in association with extensive MCD.…”

“…Previously, an association of GCMN with lissencephaly has been reported. 2 Shih et al. reported a case of neurocutaneous melanocytosis with multiple intracranial anomalies including HME and a myxoid mesenchymal cerebral tumor.…”

“…Other structural brain abnormalities are also associated with CMN such as spinal dysraphism, Dandy-Walker malformation, encephalocoele, inferior vermian hypoplasia, meningiomas, arachnoid cyst, and Chiari type I malformation. 1,2 The recent literature also describes a few rare associations of CMN and central nervous system (CNS) migrational anomalies such as focal cortical dysplasias, lissencephaly and hemimegalencephaly (HME). [2][3][4] We present a rare case of a neonate presenting with GCMN with the localized form of HME and associated posterior quadrantic dysplasia.…”

“…1,2 The recent literature also describes a few rare associations of CMN and central nervous system (CNS) migrational anomalies such as focal cortical dysplasias, lissencephaly and hemimegalencephaly (HME). [2][3][4] We present a rare case of a neonate presenting with GCMN with the localized form of HME and associated posterior quadrantic dysplasia. To the best of our knowledge, this association has never been reported.…”