A rare and important case of <i>Staphylococcus haemolyticus</i>‐associated ventricular atrial shunt nephritis

Suen, Kyle; Mashhadian, Ardavan; Figarsky, Ian; Payumo, Jeff; Liu, Antonio

doi:10.1002/ccr3.1251

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…In addition, S. haemolyticus are among the predominant organisms colonizing the periurethral and urethra in males and females, they regularly account for about 10% of UTIs [54,55]. Furthermore, S. haemolyticusassociated ventricular atrial shunt nephritis was recorded [56]. Moreover, S. haemolyticus causes meningitis in an allogeneic stem cell transplant patient following central catheterrelated bacteremia with no previous history of neurosurgical procedures [19].…”

Section: Other Human Diseasesmentioning

confidence: 99%

Clinical Infections, Antibiotic Resistance, and Pathogenesis of Staphylococcus haemolyticus

et al. 2022

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Staphylococcus haemolyticus (S. haemolyticus) constitutes the main part of the human skin microbiota. It is widespread in hospitals and among medical staff, resulting in being an emerging microbe causing nosocomial infections. S. haemolyticus, especially strains that cause nosocomial infections, are more resistant to antibiotics than other coagulase-negative Staphylococci. There is clear evidence that the resistance genes can be acquired by other Staphylococcus species through S. haemolyticus. Severe infections are recorded with S. haemolyticus such as meningitis, endocarditis, prosthetic joint infections, bacteremia, septicemia, peritonitis, and otitis, especially in immunocompromised patients. In addition, S. haemolyticus species were detected in dogs, breed kennels, and food animals. The main feature of pathogenic S. haemolyticus isolates is the formation of a biofilm which is involved in catheter-associated infections and other nosocomial infections. Besides the biofilm formation, S. haemolyticus secretes other factors for bacterial adherence and invasion such as enterotoxins, hemolysins, and fibronectin-binding proteins. In this review, we give updates on the clinical infections associated with S. haemolyticus, highlighting the antibiotic resistance patterns of these isolates, and the virulence factors associated with the disease development.

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