2020
DOI: 10.7759/cureus.7021
|View full text |Cite
|
Sign up to set email alerts
|

A Rapidly Progressive Case of Statin-induced Necrotizing Autoimmune Myopathy

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2020
2020
2024
2024

Publication Types

Select...
3

Relationship

0
3

Authors

Journals

citations
Cited by 3 publications
(1 citation statement)
references
References 14 publications
(14 reference statements)
0
1
0
Order By: Relevance
“…The first one has the potential to be used as a tool for “precision medicine.” Among the 1677 single NCBI of hHMGR, 176 are missense variants and 11 are frame-shift variants, which alters the amino acid sequence of hHMGR. Statins are one of the most commonly used medications to lower cholesterol ( Ahmed et al, 2020 ), which have been known to cause various side effects such as muscle pain, muscle weakness, rhabdomyolysis, especially high-dosage statins ( Bitzur et al, 2013 ; Ahmed et al, 2020 ; Won et al, 2020 ). By replacing the thHMGR gene with the individual’s variant in the statin-efficacy testing sensor, we can test which statin drug has the best inhibition effect on his/her HMGR activity, and what is the best dosage.…”
Section: Discussionmentioning
confidence: 99%
“…The first one has the potential to be used as a tool for “precision medicine.” Among the 1677 single NCBI of hHMGR, 176 are missense variants and 11 are frame-shift variants, which alters the amino acid sequence of hHMGR. Statins are one of the most commonly used medications to lower cholesterol ( Ahmed et al, 2020 ), which have been known to cause various side effects such as muscle pain, muscle weakness, rhabdomyolysis, especially high-dosage statins ( Bitzur et al, 2013 ; Ahmed et al, 2020 ; Won et al, 2020 ). By replacing the thHMGR gene with the individual’s variant in the statin-efficacy testing sensor, we can test which statin drug has the best inhibition effect on his/her HMGR activity, and what is the best dosage.…”
Section: Discussionmentioning
confidence: 99%