A rapidly growing facial nodule in an elderly man. Merkel cell carcinoma, with presumed metastasis to regional lymph nodes

O'Brien, Richard F.; Js, Wieselthier; Lee, Joseph; Gs, Rogers; Hk, Koh

doi:10.1001/archderm.127.4.571

Cited by 1 publication

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“…Leiomyoma of the nipple consists of interlacing bundles of smooth muscle fibers, with no or minimal intervening tissue. Glandular elements, necrosis, nuclear atypia or mitotic activity are absent within the lesion [2,9,10]. Immunohistochemically the tumor cells express desmin, SMA and vimentin but not S-100 or cytokeratin [13].…”

Section: Discussionmentioning

confidence: 99%

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A 35-year-old woman presenting with an unusual post-traumatic leiomyoma of the nipple: a case report

et al. 2013

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IntroductionLeiomyoma of the mammary papilla is one of the most uncommon nipple tumors with only 50 cases reported in the literature until now. To the best of our knowledge we present the first report of a nipple leiomyoma that originated from a traumatic abrasion caused by breastfeeding.Case presentationA 35-year-old healthy Caucasian female with a cauliflower-like tender and pink nodular mass that was approximately 10mm in diameter presented to our out-patients department. The patient suggested that the mass originated from a traumatic abrasion caused by breastfeeding three years ago and it has been slowly growing ever since.An excision biopsy was performed. The histological and immunohistochemical examination confirmed the diagnosis of leiomyoma. There were no postoperative complications or any sign of local recurrence four years postoperatively.ConclusionsLeiomyoma of the mammary papilla is a rare benign neoplasm that usually appears as a solid tender nodule. Differential diagnosis comprises breast carcinoma, leiomyosarcoma and myoid hamartoma. The recommended treatment is complete excision of the tumor with histologically confirmed tumor-free margins otherwise recurrence is possible. A detailed history of the patient’s disease can reveal the original etiology. This is an original case report that will have particular interest to plastic surgeons, dermatologists, and pathologists. The pathogenetic mechanism was trauma of the nipple. According to our review of the literature this particular information has never been reported and we think that it may advance our knowledge of this very infrequent tumor.

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Section: Discussionmentioning

confidence: 99%

“…According to our review of the literature, 50 cases have been reported to date [1-10]. There are different types of leiomyomas depending on the tissue origin, such as vascular leiomyoma (from vascular endothelium) [2] or superficial leiomyoma (from dermal smooth muscle) [3].…”

Section: Introductionmentioning

confidence: 99%