A Rapidly Converging Algorithm for Exact Binomial Confidence Intervals About the Relative Risk in Follow-up Studies with Stratified Incidence-Density Data

Guess, Harry A.; Thomas, Julie E.

doi:10.1097/00001648-199001000-00016

Cited by 19 publications

(9 citation statements)

References 5 publications

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“…When there were Ͻ11 cases, relative risk and the 95% CI were based on the ratio of event rates. 24 Blocks instead of studies were used as strata for the estimated relative risks because many studies had few or no events.…”

Section: Methodsmentioning

confidence: 99%

Cardiovascular Thrombotic Events in Controlled, Clinical Trials of Rofecoxib

et al. 2001

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Background-In comparing aspirin, nonselective nonsteroidal antiinflammatory agents (NSAIDs), and cyclooxygenase (COX)-2 inhibitors, variation in platelet inhibitory effects exists that may be associated with differential risks of cardiovascular (CV) thrombotic events. Among the randomized, controlled trials with the COX-2 inhibitor rofecoxib, one study demonstrated a significant difference between rofecoxib and its NSAID comparator (naproxen) in the risk of CV thrombotic events. A combined analysis of individual patient data was undertaken to determine whether there was an excess of CV thrombotic events in patients treated with rofecoxib compared with those treated with placebo or nonselective NSAIDs. Methods and Results-CV thrombotic events were assessed across 23 phase IIb to V rofecoxib studies. Comparisons were made between patients taking rofecoxib and those taking either placebo, naproxen (an NSAID with near-complete inhibition of platelet function throughout its dosing interval), or another nonselective NSAIDs used in the development program (diclofenac, ibuprofen, and nabumetone). The major outcome measure was the combined end point used by the Antiplatelet Trialists' Collaboration, which includes CV, hemorrhagic, and unknown deaths; nonfatal myocardial infarctions; and nonfatal strokes. More than 28 000 patients, representing Ͼ14 000 patient-years at risk, were analyzed.

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Section: Methodsmentioning

confidence: 99%

Cardiovascular Thrombotic Events in Controlled, Clinical Trials of Rofecoxib

et al. 2001

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“…10,28 statistical analysis A data-analysis plan was completed before the data were unblinded for analysis. 31,[34][35][36][37][38] The analysis was performed by the VACSP coordinating center (West Haven, Conn.), with review and approval by the executive committee of the study. Vaccine efficacy with respect to the burden of illness due to herpes zoster (VE BOI ) was defined as the relative reduction in the burden-of-illness score in the vaccine group as compared with that in the placebo group and calculated as 1¡relative risk (i.e., 1¡the herpeszoster burden-of-illness score in the vaccine group divided by the herpes-zoster burden-of-illness score in the placebo group).…”

Section: Efficacy End Pointsmentioning

confidence: 99%

A Vaccine to Prevent Herpes Zoster and Postherpetic Neuralgia in Older Adults

et al. 2005

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“…The relationship between AUI and cervical removal was similarly investigated. The data were then stratified according to whether or not the cervix was removed at spaying, and a stratified analysis for person-time data, with exact confidence intervals (Guess and Thomas 1990), was conducted to adjust for any potential confounding effect that this factor might have on the relationship between AUI and time of neutering. The validity of pooling the strata to produce a summary relative risk was assessed with a likelihood-ratio test (Rothman 1986), interpreted at the 5 per cent level of statistical significance.…”

Section: Data Storage and Analysismentioning

confidence: 99%

Acquired urinary incontinence in bitches: its incidence and relationship to neutering practices

Thrusfield

Holt

Muirhead

1998

J of Small Animal Practice

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A five-year cohort study was conducted on bitches chosen by a sample of 233 randomly selected practising veterinary surgeons in the UK, to estimate the incidence of acquired urinary incontinence (AUI) in neutered and entire animals, and to investigate possible risk factors associated with neutering practices. Information was collected using questionnaires, and data on 809 bitches, of which 22 developed AUI, were obtained. The estimated incidence rates in neutered and entire animals were 0.0174 and 0.0022 per animal-year, respectively (95 per cent confidence intervals: 0.0110, 0.0275 and 0.0009, 0.0058, respectively). The relative risk, neutered vs entire, was 7.8 (95 per cent confidence interval: 2.6, 31.5). The attributable proportion(exposed) and population attributable proportion were 87.1 per cent and 63.1 per cent (95 per cent confidence intervals: 61.9 per cent, 95.6 per cent, and 28.3 percent, 88.5 per cent, respectively). An increased risk, significant at the conventional 5 per cent level, was not demonstrated in animals neutered before, vs after, first heat (relative risk: 3.9, 95 per cent confidence interval: 0.8, 10.4), although the result was significant at the 10 per cent level. Removal of the cervix was not shown to be a risk factor in neutered dogs.

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A Rapidly Converging Algorithm for Exact Binomial Confidence Intervals About the Relative Risk in Follow-up Studies with Stratified Incidence-Density Data

Cited by 19 publications

References 5 publications

Cardiovascular Thrombotic Events in Controlled, Clinical Trials of Rofecoxib

Cardiovascular Thrombotic Events in Controlled, Clinical Trials of Rofecoxib

A Vaccine to Prevent Herpes Zoster and Postherpetic Neuralgia in Older Adults

Acquired urinary incontinence in bitches: its incidence and relationship to neutering practices

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