A rapid temperature-responsive sol–gel reversible poly(N-isopropylacrylamide)-g-methylcellulose copolymer hydrogel

Liu, Wenguang; Zhang, Bingqi; Lu, Wenqiang; Li, Xiaowei; Zhu, Dunwan; Yao, Kang; Wang, Qin; Zhao, Chengru; Wang, Chuandong

doi:10.1016/j.biomaterials.2003.09.077

Cited by 151 publications

(104 citation statements)

References 20 publications

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“…It has thermoreversible gelation properties in aqueous solutions, gelling at temperatures in the range of 60-80°C and turning into a solution upon cooling [11,20]. Liu et al [21] have grafted methylcellulose with the synthetic N-isopropylacrylamide (NiPAAm), combining the thermogelling properties of both materials. It was possible to prepare fast reversibly thermogelling hydrogels by adjusting the ratios of the two components.…”

Section: Polysaccharidesmentioning

confidence: 99%

Thermoresponsive hydrogels in biomedical applications

Klouda

Mikos

2008

European Journal of Pharmaceutics and Biopharmaceutics

1,090

696

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Environmentally responsive hydrogels have the ability to turn from solution to gel when a specific stimulus is applied. Thermoresponsive hydrogels utilize temperature change as the trigger that determines their gelling behavior without any additional external factor. These hydrogels have been interesting for biomedical uses as they can swell in situ under physiological conditions and provide the advantage of convenient administration. The scope of this paper is to review the aqueous polymer solutions that exhibit transition to gel upon temperature change. Typically, aqueous solutions of hydrogels used in biomedical applications are liquid at ambient temperature and gel at physiological temperature. The review focuses mainly on hydrogels based on natural polymers, N-isopropylacrylamide polymers, poly(ethylene oxide)-b-poly(propylene oxide)-bpoly(ethylene oxide) polymers as well as poly(ethylene glycol)-biodegradable polyester copolymers.

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Section: Polysaccharidesmentioning

confidence: 99%

Thermoresponsive hydrogels in biomedical applications

Klouda

Mikos

2008

European Journal of Pharmaceutics and Biopharmaceutics

1,090

696

View full text Add to dashboard Cite

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“…Typical temperature-responsive hydrogels exhibit markedly decreased absorbency with increasing temperature (Harsh and Gehrke 1991;Kuwabara and Kubota 1996;Çaykara et al 2006;Chang et al 2009b). Decreases in absorbency as high as a factor of five (Kuwabara and Kubota 1996) or ten (Çaykara et al 2006) have been reported when comparing absorbency at about 20 o C to the correspondding value at about 40 o C. The strongest thermal effects are for SAPs incorporating relatively high proportions of poly(N-isopropylacrylamide); these generally exhibit a strong decrease in absorbency at temperatures near to physiological conditions (Kuwabara and Kubota 1996;Liu et al 2004;Chang et al 2009b;Yang et al 2011). For example, Kuwabara and Kubota (1996) used a two-step procedure to graft a 51/49% acrylic acid/N-isopropylacyrlamide onto CMC at a grafting level of 205%; water absorbency fell from about 14 g/g at 10 o C to 3 g/g at 50 o C. Çaykara et al (2006) prepared semi-interpenetrating networks of poly-[(N-tert-butylacrylamide)-co-acrylamide] with hydroxypropylcellulose; water sorption was observed to fall from as high as 19 g/g at 5 o C down to about 2 g/g at 40 o C and above.…”

Section: Temperaturementioning

confidence: 99%

Enhanced Absorbent Products Incorporating Cellulose and Its Derivatives: A Review

Hubbe¹,

Ayoub²,

Daystar³

et al. 2013

BioResources

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Cellulose and some cellulose derivatives can play vital roles in the enhancement of the performance of absorbent products. Cellulose itself, in the form of cellulosic fibers or nano-fibers, can provide structure, bulk, water-holding capacity, and channeling of fluids over a wide dimensional range. Likewise, cellulose derivatives such as carboxymethylcellulose (CMC) have been widely studied as components in superabsorbent polymer (SAP) formulations. The present review focuses on strategies and mechanisms in which inclusion of cellulose -in its various formscan enhance either the capacity or the rate of aqueous fluid absorption in various potential applications.

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“…Examples include pH-responsive, [6,7] temperatureresponsive, [8][9][10] electroresponsive, [11][12][13][14] and photoresponsive hydrogels. [15,16] pH-responsive and temperature-responsive hydrogels have been particularly prevalent in the biomaterials science literature, with initial examples extending back to the 1980s.…”

Section: Dynamic Materials Based On Physicochemical Mechanismsmentioning

confidence: 99%

Bioinspired Design of Dynamic Materials

2009

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An emerging approach for design of dynamic materials involves mimicking natural systems, which are adept at changing their structure and function in response to their environment. Biological systems possess a diverse range of dynamic mechanisms, including competitive ligand–protein binding, enzyme‐catalyzed remodeling, and allosteric protein conformational changes. These dynamic mechanisms are now being exploited by materials scientists and engineers to design “bioinspired” synthetic materials that undergo responsive assembly and disassembly as well as dynamic volume and shape changes. The purpose of this review is to describe recent progress in design and development of bioinspired dynamic materials, with a particular emphasis on hydrogel networks. We specifically focus on emerging approaches that use biological phenomena as an inspiration for design of materials.

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A rapid temperature-responsive sol–gel reversible poly(N-isopropylacrylamide)-g-methylcellulose copolymer hydrogel

Cited by 151 publications

References 20 publications

Thermoresponsive hydrogels in biomedical applications

Thermoresponsive hydrogels in biomedical applications

Enhanced Absorbent Products Incorporating Cellulose and Its Derivatives: A Review

Bioinspired Design of Dynamic Materials

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