A Rapid Tandem Mass Spectrometric Assay for Determination of Ursolic Acid – Application to Analysis of Ursolic Acid in Four Species of Staphylea L. and Leaves of Staphylea Pinnata L. Gathered During Ontogenesis

Laciková, Ľ; Abdel-Hamid, M. E.; Novotný, Ladislav; Maśterová, I; Grančai, D

doi:10.1365/s10337-006-0724-y

Cited by 18 publications

(2 citation statements)

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“…In general, some rings opening and two different decarboxylation pathway (loss of CO 2 and HCO 2 H) were observed and the resulting fragments are depicted in Figs and . Previous mechanism studies of triterpenic acid also reported formic acid (46 Da) and CO 2 (44 Da) as two possible elimination pathways of a carboxylic function in ESI‐MS (Lacikova et al, ; Peng et al, ).…”

Section: Resultsmentioning

confidence: 99%

ESI‐MS² and Anti‐inflammatory Studies of Cyclopropanic Triterpenes. UPLC‐ESI‐MS and MS² Search of Related Metabolites from Donella ubanguiensis

Sandjo

Nascimento

Silva

et al. 2016

Phytochemical Analysis

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Section: Resultsmentioning

confidence: 99%

ESI‐MS² and Anti‐inflammatory Studies of Cyclopropanic Triterpenes. UPLC‐ESI‐MS and MS² Search of Related Metabolites from Donella ubanguiensis

Sandjo

Nascimento

Silva

et al. 2016

Phytochemical Analysis

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“…The study demonstrates that water extracts from leaves of various Staphylea L. species differ, not only in the contents of biologically active compounds, but also by the extent of harmful and beneficial effects. It is possible that other secondary metabolites, like triterpenes and steroids [18], may contribute to the observed biological activities.…”

Section: Discussionmentioning

confidence: 99%

Antiproliferative, Cytotoxic, Antioxidant Activity and Polyphenols Contents in Leaves of Four Staphylea L. Species

et al. 2009

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Staphylea has been used for long time in Traditional Chinese Medicine (TCM) and by Native Americans in a number of therapeutical indications. The present study describes in vitro antiproliferative, cytotoxic properties (MTT and LDH test) and antioxidant activities (reduction of DPPH radical and peroxynitrite radical) of Staphylea colchica Stev. (SC), S. elegans Zab. (SC), S. holocarpa Hemsl. (SH) and S. pinnata L. (SP) leave water extracts. Time- (24 and 72 h) and dose- (1-150 μg/mL) dependent effects of the above extracts were tested at the mitochondrial (MTT test) and plasma membrane level (LDH leakage) in A431 human skin carcinoma cells. Screening of these properties has shown time and dose dependent increase of harmful effects, the highest activity was observed for the SE, while the less active was the SH extract. The ED50 values for the mitochondrial and membrane damage were nearly identical for the SE and very similar for SH extract. These findings indicate simultaneous injury of both cell compartments by SE and SH extracts. The highest antioxidant potential of SE species is accompanied by the highest content of flavones/flavonols and polyphenols. Only flavonoid contents are associated with antiproliferative effects and cell membrane injury, while antioxidant properties are the result of polyphenol content. The data clearly demonstrate that individual Staphylea L. species differ, not only in the amount of biologically active compounds, but also by the extent of harmful and beneficial effects.

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Current literature in mass spectrometry

2006

J. Mass Spectrom.

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of mass spectrometry. Each bibliography is divided into 11 sections: 1 Books, Reviews & Symposia; 2 Instrumental Techniques & Methods; 3 Gas Phase Ion Chemistry; 4 Biology/Biochemistry: Amino Acids, Peptides & Proteins; Carbohydrates; Lipids; Nucleic Acids; 5 Pharmacology/Toxicology; 6 Natural Products; 7 Analysis of Organic Compounds; 8 Analysis of Inorganics/Organometallics; 9 Surface Analysis; 10 Environmental Analysis; 11 Elemental Analysis. Within each section, articles are listed in alphabetical order with respect to author (4 Weeks journals ‐ Search completed at 23rd. Aug. 2006)

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A Rapid Tandem Mass Spectrometric Assay for Determination of Ursolic Acid – Application to Analysis of Ursolic Acid in Four Species of Staphylea L. and Leaves of Staphylea Pinnata L. Gathered During Ontogenesis

Cited by 18 publications

References 9 publications

ESI‐MS² and Anti‐inflammatory Studies of Cyclopropanic Triterpenes. UPLC‐ESI‐MS and MS² Search of Related Metabolites from Donella ubanguiensis

ESI‐MS² and Anti‐inflammatory Studies of Cyclopropanic Triterpenes. UPLC‐ESI‐MS and MS² Search of Related Metabolites from Donella ubanguiensis

Antiproliferative, Cytotoxic, Antioxidant Activity and Polyphenols Contents in Leaves of Four Staphylea L. Species

Current literature in mass spectrometry

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A Rapid Tandem Mass Spectrometric Assay for Determination of Ursolic Acid – Application to Analysis of Ursolic Acid in Four Species of Staphylea L. and Leaves of Staphylea Pinnata L. Gathered During Ontogenesis

Cited by 18 publications

References 9 publications

ESI‐MS2 and Anti‐inflammatory Studies of Cyclopropanic Triterpenes. UPLC‐ESI‐MS and MS2 Search of Related Metabolites from Donella ubanguiensis

ESI‐MS2 and Anti‐inflammatory Studies of Cyclopropanic Triterpenes. UPLC‐ESI‐MS and MS2 Search of Related Metabolites from Donella ubanguiensis

Antiproliferative, Cytotoxic, Antioxidant Activity and Polyphenols Contents in Leaves of Four Staphylea L. Species

Current literature in mass spectrometry

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ESI‐MS² and Anti‐inflammatory Studies of Cyclopropanic Triterpenes. UPLC‐ESI‐MS and MS² Search of Related Metabolites from Donella ubanguiensis

ESI‐MS² and Anti‐inflammatory Studies of Cyclopropanic Triterpenes. UPLC‐ESI‐MS and MS² Search of Related Metabolites from Donella ubanguiensis