A rapid reversed phase high performance liquid chromatographic method for the determination of docetaxel (Taxotere®) in human plasma using a column switching technique

Rouini, Mohammad-Reza; Lotfolahi, A; Stewart, David J.; Molepo, J. M.; Shirazi, Farshad H.; Vergniol, Julien; Tomiak, Eva; Delorme, Fabian; Vernillet, Laurent; Giguère, Marie-Soleil; Goel, Rakesh

doi:10.1016/s0731-7085(97)00233-1

Cited by 40 publications

(21 citation statements)

References 7 publications

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“…To date, the general analytic method for DTX in biological matrices is HPLC [12,[14][15][16][17] and liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) [18][19][20][21][22][23][24][25]. The lower limit of quantitation (LLOQ) of HPLC with UV detection assays for DTX analysis has been reported to be 2.5-12.5 ng/ml in plasma [12,[14][15][16][17]. Similar LLOQ of HPLC method was also achieved in our laboratory.…”

Section: Introductionsupporting

confidence: 73%

“…One potential problem with the use of lower DTX dose is the difficulty in determining drug levels in plasma over a time frame that is necessary for the accurate assay of pharmacokinetic parameters. To date, the general analytic method for DTX in biological matrices is HPLC [12,[14][15][16][17] and liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) [18][19][20][21][22][23][24][25]. The lower limit of quantitation (LLOQ) of HPLC with UV detection assays for DTX analysis has been reported to be 2.5-12.5 ng/ml in plasma [12,[14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

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A Rapid and Sensitive UPLC–MS/MS Method for Determination of Docetaxel in Rabbit Plasma: Pharmacokinetic Study of New Lung-Targeting Docetaxel Liposome at Low Dose

Wang

Lan

Zhang

et al. 2015

Cell Biochem Biophys

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In this study, a more rapid and more sensitive ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method is developed and validated for the pharmacokinetic study of a new lung-targeting docetaxel liposome (DTX-LP) at low dose (1 mg/kg) in rabbits. The method is reliable and reproducible with intra-day precision below 5.75 %, inter-day precision below 7.57 %, and mean extraction recovery of 84.1-91.7 %. At low dose, the validated method is successfully applied to the comparative pharmacokinetic study of docetaxel (DTX) in rabbit plasma after intravenous administration of DTX-LP and DTX injection, respectively. The results indicate that the pharmacokinetic profile of DTX is completely changed when loaded in the new type of liposome, which can make DTX quicker distribution from the circulation to the target organ and slower eliminated from the body.

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Section: Introductionsupporting

confidence: 73%

Section: Introductionmentioning

confidence: 99%

A Rapid and Sensitive UPLC–MS/MS Method for Determination of Docetaxel in Rabbit Plasma: Pharmacokinetic Study of New Lung-Targeting Docetaxel Liposome at Low Dose

Wang

Lan

Zhang

et al. 2015

Cell Biochem Biophys

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“…At the assay's lower limit of quantitation (0.50 nM; 400 pg/ml), accuracy was 103% and between-run precision was 17.5%. This represents a 25-50-fold increase in sensitivity compared with analytical assays based on high-performance liquid chromatography with UV detection (22)(23)(24)(25)(26)(27)(28), although an analytical assay based on high-performance liquid chromatography with mass spectrometric detection with an lower limit of quantitation of 0.30 nM has recently been described (29). For quantitation of docetaxel in unknown samples, quality control samples at low, medium, and high concentrations were assayed in duplicate and were distributed among the calibrators and unknown samples in the analytical run; no more than 33% of the quality assurance samples were greater than Ϯ15% of the nominal concentration.…”

Section: Methodsmentioning

confidence: 99%

Comparative Pharmacokinetics of Weekly and Every-Three-Weeks Docetaxel

Baker

Zhao

Lee

et al. 2004

Clinical Cancer Research

114

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“…23,24 The LOQ for the quantification of paclitaxel was 50 ng/mL in plasma. The linear range was 0.1-40.0 µg/mL (R 2 = 0.9992) in plasma.…”

Section: Pharmacokineticsmentioning

confidence: 99%

Formulation and pharmacokinetic evaluation of a paclitaxel nanosuspension for intravenous delivery

Wang¹,

Li²,

Wang³

et al. 2011

IJN

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Paclitaxel is a diterpenoid isolated from Taxus brevifolia . It is effective for various cancers, especially ovarian and breast cancer. Due to its aqueous insolubility, it is administered dissolved in ethanol and Cremophor ® EL (BASF, Ludwigshafen, Germany), which can cause serious allergic reactions. In order to eliminate Cremophor EL, paclitaxel was formulated as a nanosuspension by high-pressure homogenization. The nanosuspension was lyophilized to obtain the dry paclitaxel nanoparticles (average size, 214.4 ± 15.03 nm), which enhanced both the physical and chemical stability of paclitaxel nanoparticles. Paclitaxel dissolution was also enhanced by the nanosuspension. Differential scanning calorimetry showed that the crystallinity of paclitaxel was preserved during the high-pressure homogenization process. The pharmacokinetics and tissue distribution of paclitaxel were compared after intravenous administration of paclitaxel nanosuspension and paclitaxel injection. In rat plasma, paclitaxel nanosuspension exhibited a significantly ( P < 0.01) reduced area under the concentration curve (AUC) 0–∞ (20.343 ± 9.119 μg · h · mL −1 vs 5.196 ± 1.426 μg · h · mL −1 ), greater clearance (2.050 ± 0.616 L · kg −1 · h −1 vs 0.556 ± 0.190 L · kg −1 · h −1 ), and shorter elimination half-life (5.646 ± 2.941 vs 3.774 ± 1.352 hours) compared with the paclitaxel solution. In contrast, the paclitaxel nanosuspension resulted in a significantly greater AUC 0–∞ in liver, lung, and spleen (all P < 0.01), but not in heart or kidney.

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A rapid reversed phase high performance liquid chromatographic method for the determination of docetaxel (Taxotere®) in human plasma using a column switching technique

Cited by 40 publications

References 7 publications

A Rapid and Sensitive UPLC–MS/MS Method for Determination of Docetaxel in Rabbit Plasma: Pharmacokinetic Study of New Lung-Targeting Docetaxel Liposome at Low Dose

A Rapid and Sensitive UPLC–MS/MS Method for Determination of Docetaxel in Rabbit Plasma: Pharmacokinetic Study of New Lung-Targeting Docetaxel Liposome at Low Dose

Comparative Pharmacokinetics of Weekly and Every-Three-Weeks Docetaxel

Formulation and pharmacokinetic evaluation of a paclitaxel nanosuspension for intravenous delivery

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