A Rapid Method for the Analysis of Ten Compounds in Psoralea corylifolia L. by UPLC

Wang, Yuefei; Wu, Bin; Yang, Jing; Hu, Limin; Su, Yi; Gao, Xiumei

doi:10.1365/s10337-009-1118-8

Cited by 27 publications

(24 citation statements)

References 26 publications

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“…Bakuchiol is the most abundant (BKC, 44.59%), followed by psoralidin (PLD, 5.5%), bavachinin (BCN, 2.16%), isobavachalcone (IBC, 1.61%), neobavaisoflavone (NBIF, 1.48%), bavachin (BC, 1.14%), isopsoralen (IPL, 1.12%) and psoralen (PL, 0.91%). This is consistent with previous reports [16,17].…”

Section: Resultssupporting

confidence: 94%

Isobavachalcone and bavachinin from Psoraleae Fructus modulate Aβ42 aggregation process through different mechanisms in vitro

2013

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a b s t r a c tSpontaneous aggregation of Ab is a key factor in the development of Alzheimer's disease. In searching for Ab aggregation inhibitors from traditional Chinese herbal medicines, we identified two active compounds from Psoraleae Fructus, namely isobavachalcone and bavachinin. We further demonstrated that the two compounds modulate Ab42 aggregation process through different mechanisms. Isobavachalcone significantly inhibits both oligomerization and fibrillization of Ab42, whereas bavachinin inhibits fibrillization and leads to off-pathway aggregation. Both of the compounds attenuated Ab42-induced toxicity in a SH-SY5Y cell model. These findings may provide valuable information for new drug development and Alzheimer's therapy in the future. Structured digital abstract:Abeta42 physically interacts with Abeta42 by two hybrid (View interaction) Abeta42 and Abeta42 bind by filter binding (View interaction) Abeta42 and Abeta42 bind by comigration in sds page (1, 2, 3) Abeta42 and Abeta42 bind by atomic force microscopy (View interaction) Abeta42 and Abeta42 bind by fluorescence technology (View interaction)

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Section: Resultssupporting

confidence: 94%

Isobavachalcone and bavachinin from Psoraleae Fructus modulate Aβ42 aggregation process through different mechanisms in vitro

2013

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“…As bavachin has structural similarity to isobavachalcone and they have the same molecular weights, it is necessary to include them in any quality assessment of traditional Chinese medicine. The analysis of P. corylifolia L. has been reported by LC 15–18 and HPLC‐MS 19, 20. For instance, ultra performance liquid chromatography‐diode array detection (UPLC‐DAD) 17 method has been used to determine ten compounds in P. corylifolia L. with limits of detection of 7.21×10 −8 mol/L for bavachin and 7.02×10 −8 mol/L for isobavachalcone.…”

Section: Introductionmentioning

confidence: 99%

Determination of bavachin and isobavachalcone in Fructus Psoraleae by high‐performance liquid chromatography with electrochemical detection

Wang

Chen

2011

J of Separation Science

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A simple, sensitive and selective method of high-performance liquid chromatography with electrochemical detection (HPLC-ECD) has been developed for simultaneous determination of bavachin and isobavachalcone in Fructus Psoraleae. It indicates that the sensitivity of electrochemical detection is ten times higher than that of diode array detection (DAD). The mean recoveries around 98% with a relative standard deviation less than 3.1% for the two analytes have been obtained. The proposed separation and detection procedures were successfully applied to the simultaneous determination of bavachin and isobavachalcone in traditional Chinese medicine.

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“…Recent studies demonstrated that psoralen and isopsoralen specifically showed estrogen-like activity [11, 12], osteoblastic proliferation accelerating activity [13, 14], anticancer activity [15], antibacterial activity [16], and so forth. However, to the best of authors' knowledge, no information was available about the tissue distribution character of the 2 compounds, and no investigation was reported comparing the fore-and-aft salt-process effect on scurfpea fruit.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Salt-Processed Psoralea corylifolia on Generative Organ Targeting

Zhao

Yan

et al. 2016

Journal of Analytical Methods in Chemistry

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Psoralen and isopsoralen are two isomers and main effective components within Psoralea corylifolia. In order to investigate the salt-processing effect on tissue distribution characters of psoralen and isopsoralen, a sensitive and accurate ultrahigh pressure liquid chromatographic tandem mass spectrometric (UHPLC-MS/MS) method has been developed and validated for simultaneous determination of the 2 components in rats' tissues after administration of the extracts that came from either crude or salt-processed Psoralea corylifolia L. Data displayed that both areas under the curve (AUC) of psoralen and isopsoralen from salt-processed scurfpea fruit group were significantly increased compared with that of the crude herb group, especially in heart (p < 0.05), ovary, and testes (p < 0.001). Though the RE and RCmax of psoralen and isopsoralen in all of the investigated organs were over 1.0, generative organs kept the maximum value. The experiment manifested that salt-processing of scurfpea fruit can increase the distribution of psoralen and isopsoralen to generative organs, heart and spleen, and the distribution of psoralen and isopsoralen to generative organs is significantly higher compared to heart and spleen (p < 0.01). Results indicate that salt-processing of scurfpea fruit can significantly increase the distribution of psoralen and isopsoralen to generative organs.

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A Rapid Method for the Analysis of Ten Compounds in Psoralea corylifolia L. by UPLC

Cited by 27 publications

References 26 publications

Isobavachalcone and bavachinin from Psoraleae Fructus modulate Aβ42 aggregation process through different mechanisms in vitro

Isobavachalcone and bavachinin from Psoraleae Fructus modulate Aβ42 aggregation process through different mechanisms in vitro

Determination of bavachin and isobavachalcone in Fructus Psoraleae by high‐performance liquid chromatography with electrochemical detection

The Effect of Salt-Processed Psoralea corylifolia on Generative Organ Targeting

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