A Rapid In Vivo Toxicity Assessment Method for Antimicrobial Peptides
Yulang Chi,
Yunhui Peng,
Shikun Zhang
et al.
Abstract:Antimicrobial peptides (AMPs) represent a promising antibiotic alternative to overcome drug-resistant bacteria by inserting into the membrane of bacteria, resulting in cell lysis. However, therapeutic applications of AMPs have been hindered by their ability to lyse eukaryotic cells. GF-17 is a truncated peptide of LL-37, which has perfect amphipathicity and a higher hydrophobicity, resulting in higher haemolytic activity. However, there is no significant difference in the cytotoxicity against human lung epithe… Show more
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