A rapid FTIR spectroscopic assay for quantitative determination of Memantine hydrochloride and Amisulpride in human plasma and pharmaceutical formulations

Atia, Noha N.; Marzouq, Mostafa A.; Hassan, Ahmed I.; Eltoukhi, Walid E.

doi:10.1016/j.saa.2020.118377

Cited by 7 publications

(5 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All peaks were present at nearly the same wave numbers, indicating that the chemical environment and bond strengths of the functional groups remained unchanged. In addition, no new peaks appeared in the formulation spectrum that would suggest the formation of new chemical bonds or degradation products due to the interaction between riboflavin and carnauba wax [27].…”

Section: Drug Excipient Incompatibility Studiesmentioning

confidence: 97%

Development and Evaluation of Gastric Floating Tablets of Riboflavin Using Box-Behnken Design

SVN,

PAPPULA,

NAIK

et al. 2023

Int J App Pharm

View full text Add to dashboard Cite

Objective: To develop and evaluate gastric floating tablets of riboflavin that was thermally fused using an experimental design method. Methods: Gastric floating tablets were developed using the Box-Behnken design. The effect of sintering on various tablet properties is assessed. The prepared floating tablets were tested for characteristics like usual tablet quality control tests with special emphasis on buoyancy studies and in vitro drug release studies. Results: The drug-excipient incompatibility studies indicated no interactions between riboflavin and carnauba wax. Sintering the powder at 1200, °C partially decreased its crystallinity and improved drug release for up to 16 h. The tablets demonstrated good flow properties, acceptable hardness, low friability, and uniformity in thickness and diameter. Statistical models successfully optimized the formulation to achieve desired characteristics and practical compressibility. The optimal amounts of the variables, according to Design Expert® 12 software, were 59.19 mg of carnauba wax, 14.63% w/w of sodium bicarbonate, a sintering temperature of 74.68 °C, and a sintering exposure time of 1.99 h. Conclusion: In vitro dissolution studies were conducted on the optimized formulation to verify the model's predictions. The experimental results closely matched the predictions. The optimized formulations showed a floating lag time of 104 seconds and a floating duration of 12.3 h. The obtained T90 was found to be 11.3 h which followed zero order kinetics with a non-Fickian diffusion mechanism.

show abstract

Section: Drug Excipient Incompatibility Studiesmentioning

confidence: 97%

Development and Evaluation of Gastric Floating Tablets of Riboflavin Using Box-Behnken Design

SVN,

PAPPULA,

NAIK

et al. 2023

Int J App Pharm

View full text Add to dashboard Cite

show abstract

“…Fourier transform infrared (FTIR) spectroscopy was used to assess potential interactions between memantine hydrochloride (MH) and the excipients in the transdermal patch. FTIR spectra of physical mixtures of pure MH and each excipient were obtained using the KBr pellet method with an FTIR spectrophotometer (Perkin-Elmer 1600, Thane) over the range of 4000 to 400 cm−1 [17] By comparing the spectra of the physical mixtures with the spectra of the pure components, any shifts or changes in peaks could indicate possible interactions between MH and the excipients. FTIR was used to verify that there were no incompatible interactions that could impact the stability or performance of the transdermal patch.…”

Section: Drug-excipient Incompatibility Studiesmentioning

confidence: 99%

“…5. By comparing the spectra, FTIR can reveal any interactions between a drug and excipients that could impact stability or performance [17]. In this case, the lack of changes shows that MH is compatible with the excipients in the transdermal patch.…”

Section: Standard Calibration Curve a Uv-visible Spectroscopymentioning

confidence: 99%

Design, Development, and Evaluation of Transdermal Patches Containing Memantine Hydrochloride

VALEVETI,

PASHIKANTI

2023

Int J App Pharm

View full text Add to dashboard Cite

Objective: This study aimed to develop an effective transdermal drug delivery system of memantine hydrochloride (MH), an anti-Alzheimer's drug, to improve patient compliance and optimize drug therapy in patients with dementia who often have difficulties adhering to oral medication schedules. Methods: Various transdermal patches of MH were prepared using the box-Behnken design of experiments with different polymer combinations. The fabricated patches were evaluated for properties like thickness, folding endurance, drug content uniformity, in vitro drug release, and diffusion studies. An optimal formulation was selected based on the results and further studied for pharmacokinetic parameters in rabbits. The results were compared to conventional tablets containing the same polymer combination. Results: Formulation B2 containing Hydroxy Propyl Methyl Cellulose (HPMC) 137.5 mg, Ethyl Cellulose (EC) 400 mg, and xanthan gum 300 mg had a flux of 212.24 μg/cm2/h, the permeability of 2.32 cm/h, and 27.95% release at 8h, with first-order and non-Fickian drug release kinetics. It was non-irritating, and in vitro release studies showed sustained release for up to 48 h. In vivo studies in rabbits also indicated superior drug absorption and sustained release from the patches compared to tablets. Conclusion: The optimized transdermal patch formulation had the potential to provide a prolonged release of MH for over 2 d and reduce the frequency of dosing. However, further studies are warranted to confirm the efficacy, safety, and pharmacokinetics of the patches in human models before clinical use.

show abstract

“…Spectra of the physical mixtures compared to pure components to determine peak shifts or changes and assess possible DH-excipient interactions. 13,15 Evaluation of Prepared Transdermal Patches…”

Section: Construction Of Standard Calibration Curvementioning

confidence: 99%

Design, Development, and Evaluation of Transdermal Patches Containing Donepezil Hydrochloride

SK,

2022

IJDDT

View full text Add to dashboard Cite

This study aimed to develop a donepezil hydrochloride (DH) transdermal drug delivery system to address non-compliance due to dementia in Alzheimer’s patients. DH has a low dose, balanced hydrophilicity/lipophilicity, and low toxicity making it suitable for transdermal. DH transdermal patches were prepared using a polymer and plasticizer matrix system via box-Behnken design and evaluated for properties. Formulation B2 containing hydroxy propyl methyl cellulose (HPMC), ethyl cellulose (EC), and xanthan gum was optimal, exhibiting a maximum of ~99.17% in-vitro drug release for 48 hours. In-vivo pharmacokinetic parameters studied in rabbits were superior to commercial DH tablets. The study demonstrates the potential for DH transdermal patches as an alternative to oral medication for Alzheimer’s patients. The patches can provide sustained release for prolonged periods without requiring multiple doses. However, further confirmation is needed via in-vivo pharmacodynamic and human pharmacokinetic studies.

show abstract

A rapid FTIR spectroscopic assay for quantitative determination of Memantine hydrochloride and Amisulpride in human plasma and pharmaceutical formulations

Cited by 7 publications

References 20 publications

Development and Evaluation of Gastric Floating Tablets of Riboflavin Using Box-Behnken Design

Development and Evaluation of Gastric Floating Tablets of Riboflavin Using Box-Behnken Design

Design, Development, and Evaluation of Transdermal Patches Containing Memantine Hydrochloride

Design, Development, and Evaluation of Transdermal Patches Containing Donepezil Hydrochloride

Contact Info

Product

Resources

About