A Rapid, Endoscopic Exocrine Pancreatic Function Test and the Lundh Test: A Comparative Study

Exocrine pancreatic function in hepatocyte nuclear factor 1β‐maturity‐onset diabetes of the young (HNF1B‐MODY) is only moderately reduced: compensatory hypersecretion from a hypoplastic pancreas

“…In addition, we performed a rapid endoscopic secretin test to determine pancreatic exocrine function. This test has proven to be reliable, easy to perform and well tolerated by patients [20][21][22]. We found lower levels of bicarbonate in secretin-stimulated duodenal juice from the HNF1B mutation carriers compared with healthy controls, confirming lower pancreatic ductal function.…”

Assessment of exocrine pancreatic function by secretin‐stimulated magnetic resonance cholangiopancreaticography and diffusion‐weighted imaging in healthy controls

“…Bicarbonate concentration in duodenal fluid is considered one of the most reliable biochemical markers of pancreatic exocrine function . We found that peak bicarbonate concentration was positively correlated with secreted pancreatic volumes at 1 minute postsecretin with the same tendency also at 5, 9, and 13 minutes postsecretin.…”

“…Ten subjects had gastroscopy with duodenal intubation using a rapid endoscopic aspiration‐based test . The participants fasted >8 hours and the procedure commenced 25 minutes after administration of intravenous (IV) injection of secretin (1 CU/kg, maximum dose 70 CU; Secrelux, Sanochemia, Neuss, Germany).…”

Zinc, Copper and Oxidative stresses in Chronic Pancreatitis

“…Previous studies had reported that pancreatic Zn output correlated strongly with enzyme secretion 10 . Despite the initial enthusiaism of using Zn concentration in secretin-stimulated duodenal juice as a potent measure of pancreatic exocrine insufficiency, this was not validated in independent cohorts later on [14][15][16] . Thus direct measurements of Zn in pancreatic exocrine secretions as a measure of pancreatic exocrine insufficiency underwent a silent burial.…”