A rapid drug release system with a NIR light-activated molecular switch for dual-modality photothermal/antibiotic treatments of subcutaneous abscesses

Chiang, Wei-Lun; Lin, Tzu-Tsen; Sureshbabu, Radhakrishnan; Chia, Wei-Tso; Hsiao, Hsu-Chan; Liu, Hung‐Yi; Yang, Chih-Man; Sung, Hsing‐Wen

doi:10.1016/j.jconrel.2014.12.011

Cited by 108 publications

(87 citation statements)

References 46 publications

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“…In addition, thermoresponsive nanocarriers have been utilized in multi-stimuli-responsive delivery systems. For example, dual stimuli-responsive systems, e.g., temperature/pH-responsive polymeric NPs, 43 pH/thermosensitive microcontainers, 45 pH/thermosensitive core–shell nanostructures, 39 and triple-stimul-responsive systems, e.g., thermo-, pH-, and reduction-sensitive polymeric micelles 46 and glucose-, pH-, and thermoresponsive nanogels 47 have been reported so far.…”

Section: Introductionmentioning

confidence: 99%

Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances

Karimi

Zangabad

Ghasemi

et al. 2016

ACS Appl. Mater. Interfaces

317

212

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Smart drug delivery systems (DDSs) have attracted the attention of many scientists, as carriers that can be stimulated by changes in environmental parameters such as temperature, pH, light, electromagnetic fields, mechanical forces, etc. These smart nanocarriers can release their cargo on demand when their target is reached and the stimulus is applied. Using the techniques of nanotechnology, these nanocarriers can be tailored to be target-specific, and exhibit delayed or controlled release of drugs. Temperature-responsive nanocarriers are one of most important groups of smart nanoparticles (NPs) that have been investigated during the past decades. Temperature can either act as an external stimulus when heat is applied from the outside, or can be internal when pathological lesions have a naturally elevated termperature. A low critical solution temperature (LCST) is a special feature of some polymeric materials, and most of the temperature-responsive nanocarriers have been designed based on this feature. In this review, we attempt to summarize recent efforts to prepare innovative temperature-responsive nanocarriers and discuss their novel applications.

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Section: Introductionmentioning

confidence: 99%

Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances

Karimi

Zangabad

Ghasemi

et al. 2016

ACS Appl. Mater. Interfaces

317

212

View full text Add to dashboard Cite

show abstract

“…This effective NIR irradiation control showed a typical switch on/off effect. It is well known that diffusion is the typical drug release mechanism for drug loaded fibers in the early stage owing to the slow degradation of PLLA, thus the mobility of polymer chains seems play the dominant role [14,33]. Though bulk PLLA was semi-crystalline polymer material [34], XRD results demonstrated that all fibers were amorphous and incorporation of MWCNTs and DOX in the materials would not change the physical state of fibers (Fig.S3).…”

Section: Characterization Of Fiber Matsmentioning

confidence: 95%

Electrospun PLA/MWCNTs composite nanofibers for combined chemo- and photothermal therapy

et al. 2015

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“…In view of this, a strategy to combine with other antimicrobial therapeutic modality will be advantageous to achieve a successful eradication of pathogens, which could reduce potential for non-specific thermal damage to host cells by enabling the use of reduced level of NIR light intensity. Recently, Chiang et al [115] successfully applied a dual modalities of therapeutic platform for treating wound infection by combining a platform for NIR light-triggered hyperthermia with one for controlled release of antibiotics. For this, they have developed a hybrid microsphere made of a shell of PLGA and aqueous cores composed of polypyrrole nanoparticles and vancomycin, in which polypyrrole nanoparticles were used as a photothermal agent.…”

Section: Nanoparticle-based Strategies For Controlling Biofilm Infmentioning

confidence: 99%

Nanoparticle-Based Therapies for Wound Biofilm Infection: Opportunities and Challenges

Kim

2016

IEEE Trans.on Nanobioscience

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Clinical data from human chronic wounds implicates biofilm formation with the onset of wound chronicity. Despite the development of novel antimicrobial agents, the cost and complexity of treating chronic wound infections associated with biofilms remain a serious challenge, which necessitates the development of new and alternative approaches for effective anti-biofilm treatment. Recent advancement in nanotechnology for developing a new class of nanoparticles that exhibit unique chemical and physical properties holds promise for the treatment of biofilm infections. Over the last decade, nanoparticle-based approaches against wound biofilm infection have been directed toward developing nanoparticles with intrinsic antimicrobial properties, utilizing nanoparticles for controlled antimicrobials delivery, and applying nanoparticles for antibacterial hyperthermia therapy. In addition, a strategy to functionalize nanoparticles towards enhanced penetration through the biofilm matrix has been receiving considerable interest recently by means of achieving an efficient targeting to the bacterial cells within biofilm matrix. This review summarizes and highlights the recent development of these nanoparticle-based approaches as potential therapeutics for controlling wound biofilm infection, along with current challenges that need to be overcome for their successful clinical translation.

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A rapid drug release system with a NIR light-activated molecular switch for dual-modality photothermal/antibiotic treatments of subcutaneous abscesses

Cited by 108 publications

References 46 publications

Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances

Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances

Electrospun PLA/MWCNTs composite nanofibers for combined chemo- and photothermal therapy

Nanoparticle-Based Therapies for Wound Biofilm Infection: Opportunities and Challenges

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