A rapid and simple colorimetric test for 2,2,2-cryptand (Kryptofix 2.2.2.) in solution

Abstract

A new and versatile method for 2,2,2-cryptand determination in [ 18 F]-labeled radiotracers is described. Proof of concept and applicability of the test method for the commercial radiotracer [ 18 F]-FDG and model compounds FLT and FMISO were also proven.

18F-labelling innovations and their potential for clinical application

“…The techniques used include simple TLC [249][250][251][252], GC [253], HPLC [245,252], and capillary electrophoresis [247], but also highly-sophisticated LC-MS analytics [254]. A novel and simple method makes use of the colour change of I2/Isolutions [255].…”

Recent Progress toward Microfluidic Quality Control Testing of Radiopharmaceuticals

“…Other colorimetric K222 indicator chemistries can likely be used in microfluidic devices as well. Anzellotti et al reported an evaluation of the I 2 /I − indicator for testing PET radiopharmaceuticals and suggested that it could be used to test sample volumes as low as 2–25 µL [ 99 ]. Experiments showed that the color change occurred within 1–2 s, and that the indicator was unaffected by the presence of several salts or amine-containing PET tracers in the formulation.…”

Immobilization of nickel on Kryptofix 222 modified Fe3O4@PEG core‐shell nanosphere for the clean synthesis of 2‐Aryl‐2,3‐dihydroquinazolin‐4(1H)‐ones

“…[ 9–13 ] They are macro‐bicyclic ligands in three forms of exo‐exo , exo‐endo , and endo‐endo [ 14 ] that have high affinity to binding spherical cations. [ 15 ] Recently, Kryptofix 222 has been applied for some pharmaceutical reactions and processes such as dissolving K + salts in nucleophilic [ 18 F]labeled radiotracers, [ 12 ] radium in radiochemical and radiopharmaceutical applications, [ 16 ] and complexation of other metal cations. [ 17 ]…”

“…[8] On the other hand, the kryptofix compounds are a specific class of aza-crown ether that is used in supramolecular chemistry materials science, catalysis, separation, and biomedicine. [9][10][11][12][13] They are macro-bicyclic ligands in three forms of exo-exo, exo-endo, and endo-endo [14] that have high affinity to binding spherical cations. [15] Recently, Kryptofix 222 has been applied for some pharmaceutical reactions and processes such as dissolving K + salts in nucleophilic [ 18 F]labeled radiotracers, [12] radium in radiochemical and radiopharmaceutical applications, [16] and complexation of other metal cations.…”

“…[9][10][11][12][13] They are macro-bicyclic ligands in three forms of exo-exo, exo-endo, and endo-endo [14] that have high affinity to binding spherical cations. [15] Recently, Kryptofix 222 has been applied for some pharmaceutical reactions and processes such as dissolving K + salts in nucleophilic [ 18 F]labeled radiotracers, [12] radium in radiochemical and radiopharmaceutical applications, [16] and complexation of other metal cations. [17] Developing quinazolinone compounds utilizing more environmentally friendly catalysts has led to broad interdisciplinary attention research due to their possible pharmaceutical and biological activities.…”