A Rapid and Accurate Method for the Determination of Urea in Blood

Leiboff, S.L.; Kahn, Bernard S.

doi:10.1016/s0021-9258(18)77123-8

Journal of Biological Chemistry

1929

DOI: 10.1016/s0021-9258(18)77123-8

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A Rapid and Accurate Method for the Determination of Urea in Blood

S.L. Leiboff

Bernard S. Kahn

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1970

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Urea Clearance in Normal and in Dehydrated Infants

SCHOENTHAL¹

1933

Am J Dis Child

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A large number of investigators have measured the end-products of nitrogen metabolism in the blood and their excretion in the urine in health and in disease as an aid in evaluating the functional capacity of the kidneys. Ambard and Weill 1 were the first to relate the concentration of urea in the blood to its concentration in the urine and to the urinary volume as expressed by "Ambard's coefficient." Addis and his collaborators 2 showed that more constant results could be obtained if, under standard conditions of fluid intake, the rate of urea excretion was measured as ureain 1 hour's u r i n e u r e a i n 100 cc. of b l o o d . They introduced the assumption, and supported it by animal experiments, that the weight of the kidney is proportional to surface area rather than body weight, which was used by Ambard. Under Addis' standard conditions the volume of urine in normal persons was above 2 cc. per minute.Van Slyke and his co-workers3 supplied an explanation for the constancy of Addis' ratio. They observed that above a certain urinary This investigation was assisted by the Josiah Macy, Jr., Foundation. From the

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Urea Clearance in Normal and in Dehydrated Infants

SCHOENTHAL¹

1933

Am J Dis Child

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The Biochemical Study of Sinus Disease

Israel¹

1931

JAMA

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An improved method for determination of total hydroxyproline in urine

Parekh

Jung

1970

Biochemical Medicine

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A Rapid and Accurate Method for the Determination of Urea in Blood

Cited by 5 publications

References 5 publications

Urea Clearance in Normal and in Dehydrated Infants

Urea Clearance in Normal and in Dehydrated Infants

The Biochemical Study of Sinus Disease

An improved method for determination of total hydroxyproline in urine

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