A randomized two-way crossover bioequivalence study in healthy adult volunteers of paediatric zidovudine/lamivudine/nevirapine fast-disintegrating fixed-dose combination tablet

Joshi, Anjali; Gbadero, Daniel; Esseku, Fredrick; Adesanya, Olufikayo J; Adeyeye, Moji Christianah

doi:10.1111/jphp.12666

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…This finding is not surprising, given that HBCR allows for the enrollment of patients who are unable to travel, a common reason given for lack of participation in CBCR. 44 , 45 , 46 However, this finding is important, given the recent nationwide increase in referrals to HBCR that occurred after the unexpected widespread closure of CBCR programs following the onset of the COVID-19 pandemic and the subsequent call from medical societies to continue to increase participation in HBCR in all eligible patients in the current pandemic era. 47 , 48 …”

Section: Discussionmentioning

confidence: 99%

Comparison of Home-Based vs Center-Based Cardiac Rehabilitation in Hospitalization, Medication Adherence, and Risk Factor Control Among Patients With Cardiovascular Disease

et al. 2022

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Key Points Question What are the associations of home-based vs center-based cardiac rehabilitation (CR) with hospitalizations, medication adherence, and cardiovascular risk factor control among diverse patients with cardiovascular disease and high risk? Findings In this cohort study of 2556 demographically diverse patients with high risk in a large integrated health system, there were fewer hospitalizations at 12 months among participants in home-based CR compared with participants in center-based CR programs. Meaning This cohort study found that participation in home-based CR was associated with fewer hospitalizations at 12 months compared with participation in center-based CR.

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Section: Discussionmentioning

confidence: 99%

Comparison of Home-Based vs Center-Based Cardiac Rehabilitation in Hospitalization, Medication Adherence, and Risk Factor Control Among Patients With Cardiovascular Disease

et al. 2022

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Formulation, Development and Scale-Up of Fixed-Dose Combination Tablets Containing Zidovudine, Lamivudine and Nevirapine

Lavra

Medeiros

Silva

et al. 2019

CHR

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Background: The development of antiretroviral associations in a single dosage form aims to ensure improved efficacy, low costs and better adherence to treatment. Objective: This work performed the pharmacotechnical development, coating, and stability studies of fixed-dose combination tablets of zidovudine, lamivudine and nevirapine (300 + 200 + 150 mg, respectively). Methods: Qualitative and quantitative planning of diluents (101 and 250 microcrystalline cellulose, spray-dried monohydrate lactose and corn starch) and coating polymers (Opadry white II HP® and Instacoat Aqua Moistshield II®) were analyzed, and direct compression (DC) and wet granulation (WG) methods were tested aiming the development of the pharmaceutical form. Quality control was carried out according to the specifications set by official compendia. The chosen formulation was scaled-up and the industrial batches were submitted to accelerated and long-term stability studies. Results: The batches obtained by WG met the requirements, using 101 microcrystalline cellulose, corn starch and Opadry white II HP® as excipients. The DC trial was not possible due to the need of a greater ratio of excipients to improve formulation properties. Conclusion: Thus, this study brings a new therapeutic alternative for HIV treatment, contributing to the development of another possibility to simplify drug administration.

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A randomized two-way crossover bioequivalence study in healthy adult volunteers of paediatric zidovudine/lamivudine/nevirapine fast-disintegrating fixed-dose combination tablet

Abstract: The developed FDC tablet is bioequivalent to the reference product.

Cited by 2 publications

References 8 publications

Comparison of Home-Based vs Center-Based Cardiac Rehabilitation in Hospitalization, Medication Adherence, and Risk Factor Control Among Patients With Cardiovascular Disease

Comparison of Home-Based vs Center-Based Cardiac Rehabilitation in Hospitalization, Medication Adherence, and Risk Factor Control Among Patients With Cardiovascular Disease

Formulation, Development and Scale-Up of Fixed-Dose Combination Tablets Containing Zidovudine, Lamivudine and Nevirapine

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