A randomized trial on the effects of CitrusiM® (Citrus sinensis (L.) Osbeck dried extract) on body composition

Abstract

Objective: In this report, we investigated the effects of CitrusiM® (Citrus sinensis (L.) Osbeck dried extract) on body composition, defined in terms of two outcomes: percentage of lean mass and percentage of fat mass. Research methods & procedures: A double-blind randomized experiment with overweight and obese volunteers was conducted in which the two variables were measured at baseline and three months afterwards. The treatment levels corresponded to three different daily doses of CitrusiM ® : 0 mg (control), 0.5 g, and 1 g. All patients met with a nutritionist, and were given a standardized diet with their assigned treatments. At the end of three months, the intermediate outcomes of diet compliance (in percent) and amount of exercise (either none, low level, or high level) were recorded. The covariates that were collected for each subject were age, height, and sex. We analyzed the effects of the treatments on the two outcomes under a Bayesian framework of the Rubin Causal Model, and accounted for possible relationships between both diet compliance and exercise level and the three outcomes of interest in the analyses. Study registered under Research Ethics Committee of the Faculdade de Ciências M edicas

Citrus species: Modern functional food and nutraceutical-based product ingredient

“…Additionally, the same treatment in 3T3-L1 adipocytes determined a reduction of lipid droplets regulating adipogenesis and thermogenesis via AMP-activated protein kinase alpha (AMPKα) pathway (Park et al, 2019). Kegele et al (2019) investigated the effects of CitrusiM® (Citrus sinensis dried extract) on body composition: percentage of lean mass and percentage of fat mass. This extract determined a significant reduction of fat, and increase in lean mass reducing waist circumference after a dose of 0.5 or 1 g/day.…”

Quality of Dry Extracts of Citrus sinensis (L.) Osbeck Juices

“…It has been suggested that anthocyanins provide protection against oxidative stress, coronary heart diseases, certain cancers, and other age-related diseases (Amorini et al 2003;Shu et al 2023). Dry extract of the Moro orange juice is widely used as a food supplement for disease prevention and obesity control, as investigated by in vivo (Titta et al 2010) and clinical studies (Cardile et al 2015; Kegele et al 2019). Its possible anti-in ammatory activity, and its potential to improve endothelial function and reduce in ammation in nondiabetic subjects with increased cardiovascular risk, have also been demonstrated (Buscem et al 2012).…”