A randomized trial of preoperative radiotherapy in cancer of the oropharynx and hypopharynx

Strong, M. Stuart; Vaughan, Charles W.; Kayne, Herbert L.; Aral, Isamettin M.; Ucmakli, Alptekin; Feldman, Merrill I.; Healy, Gerald B.

doi:10.1016/0002-9610(78)90268-4

Cited by 56 publications

(19 citation statements)

References 7 publications

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“…It was not until 1978 that Strong et al . showed clinically for the first time the unexpected correlation between radiation exposure of a primary tumor and a higher incidence of metastasis in head and neck patients, even though there was no difference in the local recurrence and overall cure rate of the two groups [15]. This effect was also noted in other clinical trials, which showed that subcurative treatments including radiotherapy of advanced carcinomas of the bladder and the uterine cervix led to increased metastatic disease [16, 17].…”

Section: Effects Of Radiation On Local and Distant Sitesmentioning

confidence: 76%

Effects of radiation on metastasis and tumor cell migration

Vilalta

Rafat

Graves

2016

Cell. Mol. Life Sci.

111

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It is well known that tumor cells migrate from the primary lesion to distant sites to form metastases and that these lesions limit patient outcome in a majority of cases. However the extent to which radiation influences this process and to which migration in turn alters radiation response remains controversial. There are preclinical and clinical reports showing that focal radiotherapy can both increase the development of distant metastasis, as well as that it can induce the regression of established metastases through the abscopal effect. More recently, preclinical studies have suggested that radiation can attract migrating tumor cells and may thereby facilitate tumor recurrence. In this review, we summarize these phenomena and their potential mechanisms of action, and evaluate their significance for modern radiation therapy strategies.

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Section: Effects Of Radiation On Local and Distant Sitesmentioning

confidence: 76%

Effects of radiation on metastasis and tumor cell migration

Vilalta

Rafat

Graves

2016

Cell. Mol. Life Sci.

111

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“…In addition, there wer_ e 5 other patients who de· veloped 7 primary malignancies outside of the head and neck. Thus, 25 of the patients (29 %) presented with other primary malignancies either before or after their pyriform sinus lesion. Of note is 1 patient who had 4 separate primary carcinomas within the head and neck over a period of 8 years: pyriform sinus, soft palate, tonsil and posterior pharyngeal wall (Table VIII).…”

Section: Resultsmentioning

confidence: 99%

Carcinoma of the Pyriform Sinus: Analysis of 102 Cases

et al. 1983

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The treatment of 102 patients with squamous cell carcinoma of the pyriform sinus seen at the University of Virginia Medical Center from 1958 through 1977 is reviewed. Eight-seven cases form the basis for this report. Surgery alone, radiation alone and combination of the two were the treatment modalities utilized for the patients in this study. The overall 3 year, no evidence of disease determinate survival was (37%). Recent literature has suggested that preoperative radiation obscures tumor margins with a decrease in survivals as compared to postoperative irradiation. Though the number of patients in both the preoperative (27) and postoperative (7) groups are small, our data suggests similar survivals. In addition, when pathology was examined, no tumor margins were transected in the preoperative irradiation group and only 5/23 patients had margins classified as close. The incidence of postoperative complications was not significantly difference between the combination therapy and surgery only groups. It is concluded that preoperative irradiation does not compromise the resection of adequate tumor margins nor significantly increase postoperative complications.

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“…Whether preoperative adjuvant radiotherapy improves the oncologic prognosis for patients with hypopharyngeal cancer remains controversial. 27 A few randomized controlled studies in the 1970s and 1980s demonstrated that preoperative radiotherapy was inferior to postoperative radiotherapy in terms of survival rate and postoperative complications. Compared to adding chemotherapy to locoregional treatment, preoperative radiation therapy alone has been shown to have an unfavorable effect on overall survival.…”

Section: Discussionmentioning

confidence: 99%