A randomized trial of mifepristone in combination with misoprostol administered sublingually or vaginally for medical abortion at 13–20 weeks gestation

Abstract

Sublingual administration of misoprostol following mifepristone is an acceptable and effective alternative to vaginal administration for medical abortion at 13-20 weeks gestation. However, women should be advised about the greater likelihood of requiring stronger analgesia.

Combined use of intracervical foley catheter and vaginal misoprostol for termination of second trimester pregnancy: a three-year observational study

“…There is a gradual increase in second-trimester abortion because of wide scale introduction of prenatal screening programs detecting women whose pregnancies are complicated by serious fetal abnormalities such as cardiovascular and skeletal malformation [2]. The most efficacious regimen for medical second trimester termination of pregnancy appears to be the use of a combination of mifepristone, followed by misoprostol [3][4][5]. This regimen has had 97-99% rate of abortion within 24 hours [3,6].…”

“…The most efficacious regimen for medical second trimester termination of pregnancy appears to be the use of a combination of mifepristone, followed by misoprostol [3][4][5]. This regimen has had 97-99% rate of abortion within 24 hours [3,6]. In countries where mifepristone is not available or affordable, gemeprost or misoprostol alone have been shown to be effective, although a higher total dose is needed and is less effective than the combined regimens [7].…”

Mifepristone with Misorostol for Mid- Trimester Abortion – A Prospective Study

“…(3,8,9) Treatment with mifepristone softenes the cervix, increases sensitivity of uterus to prostaglandins. The maximum effect on uterine contractility and cervical ripening is seen after 36-48 hours.…”

“…In study by Aggarwal N et al (10), 2.5% of patients aborted with mifepristone alone whereas other studies have reported 0.2% -0.5% incidence of complete abortion with only mifepristone. (5,8,14) There were seven patients in our study who had undergone caesarean section prior to present pregnancy. All of them had complete abortion with combination of mifepristone and Misoprostol regimen.…”

“…The combination of mifepristone followed by misoprostol has been found safe and effective for mid trimester termination of pregnancy in various studies. (3,8,9) The present study was conducted to find effectiveness of combination of Mifepristone and successive doses of vaginal misoprostol for mid-trimester abortions, to observe the course and outcome of abortion using the above protocol and to study any side effects of the above regimen.…”