A randomized trial of Korodin® Herz-Kreislauf-Tropfen as add-on treatment in older patients with orthostatic hypotension

A systematic review of the pharmacological management of orthostatic hypotension

“…Kroll et al. report that the median reduction in MAP was less with Korodin (11.4 mmHg) compared with placebo (14.0 mmHg). The box and whisker plots clearly in the publication illustrate both a deterioration and improvement in MAP for both single dose and with 1 week of application.…”

“…Eight long‐term studies fulfilled selection criteria for inclusion in the systematic review, their characteristics and risk of bias are shown in Tables and , respectively, with the full compilation of results being available online (Supplementary Table 1). There was considerable variability between these eight studies in terms of what comparable data parameters and respective standard deviations were presented making it difficult to carry out a meta‐analysis.…”

A Systematic Review of the Efficacy of Bioactive Compounds in Cardiovascular Disease: Carbohydrates, Active Lipids and Nitrogen Compounds

“…The main outcomes of the interventions regarding norbornanes were BP and HR (table 2). One study developed two interventions with 57 orthostatic hypotensive patients >50 years [24]: 75 drops/day Korodins (Herz-Kreislauf-Tropfen®) for 7 days, and a single dose of 25 Korodins drops evaluated at 1, 3, 5, 8 and 10 min. Significant changes were observed in the first intervention; thus, orthostatic hypotensive decreased.…”

“…The three articles selected investigated their actions in hypotensive subjects, two of them in orthostatic hypotensive [24,25,26]. The combination of natural D-camphor and an extract of fresh crataegus berries (Korodin Herz-Kreislauf-Tropfen®) with a single dose of 25 drops increased BP almost immediately after application [25]; as the same pattern repeated with a dose of 80 drops after 1, 3 and 5 min [26].…”

“…The combination of natural D-camphor and an extract of fresh crataegus berries (Korodin Herz-Kreislauf-Tropfen®) with a single dose of 25 drops increased BP almost immediately after application [25]; as the same pattern repeated with a dose of 80 drops after 1, 3 and 5 min [26]. After one week, 75 drops/day also increase BP [24] in hypotensive subjects.…”