A randomized trial of intravenous glutamine supplementation in trauma ICU patients

Pérez-Bárcena, Jon; Marsé, P.; Zabalegui-Pérez, Arturo; Corral, Esther; Herrán-Monge, Rubén; Gero-Escapa, María; Cervera, Mercedes; Llompart‐Pou, Juan Antonio; Ayestarán, Ignacio; Raurich, J. M.; Oliver, Antonio; Buño, Antonio; Lorenzo, A. García de; Frontera, Guiem

doi:10.1007/s00134-014-3230-y

Cited by 30 publications

(19 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We appreciate the comments by Ozcelik et al [1] on our paper on intravenous glutamine supplementation in trauma ICU patients [2]. We agree with Ozcelik on the complex interdependence effects of pharmaconutrients in critically ill patients.…”

Section: Dear Editorsupporting

confidence: 52%

A randomized trial of intravenous glutamine supplementation in trauma ICU patients: response to the comments by Ozcelik et al.

et al. 2014

Self Cite

View full text Add to dashboard Cite

Section: Dear Editorsupporting

confidence: 52%

A randomized trial of intravenous glutamine supplementation in trauma ICU patients: response to the comments by Ozcelik et al.

et al. 2014

Self Cite

View full text Add to dashboard Cite

“…A separate group of researchers recently conducted a randomized, multicenter trial to evaluate to effect of 5-day intravenous (IV) glutamine supplementation on trauma ICU patients, finding that 60% of patients had low-plasma glutamine levels, which persisted in 39% of the treated group following randomization to receive 0.5 g/kg/weight IV glutamine. 93 Low-plasma glutamine was also associated with higher rates of infection (59% vs 81%; P = .032), longer ICU (9 vs 20 days; P = .01), and hospital LOS (24 vs 41 days; P = .01) compared with those who received placebo. This is concerning because not only did high-dose supplementation fail to achieve normal plasma glutamine levels, but the dose used was that in which researchers in the previously discussed metaanalysis described a risk factor for increased mortality among critically ill patients.…”

Section: Immunonutrition and Immune-modulating Formulasmentioning

confidence: 89%

Enteral Nutrition Formula Selection

2014

View full text Add to dashboard Cite

Many new enteral nutrition (EN) formulas have been created over the past several decades with a variety of intended uses. Although each is intended to promote improved outcomes, research is often unclear and, in many cases, conflicting. It is important to note that EN products are considered medical foods by the U.S. Food and Drug Administration and therefore do not have to complete premarket review or approval and are not regulated to the same extent as pharmaceuticals. While standard EN formulas are designed to meet the basic macro- and micronutrient requirements of individuals who cannot meet nutrition needs orally, specialty EN products have been developed to exhibit pharmacologic properties, such as immune-enhancing formulas containing arginine, glutamine, nucleotides, and ω-3 fatty acids. With the vast number of products available, rising costs of healthcare, and the drive toward evidence-based practice, it is imperative that clinicians carefully consider research regarding use of specialty formulas, paying close attention to the quality, patient population, clinical end points, and cost to patient and/or facility.

show abstract

“…Recently, Perez-Barsena et al again did not find any beneficial effect of glutamine during 5 days of administration in terms of prevention of new infections. Low levels of glutamine remain unchanged despite administration and were associated as worse outcome [47]. However, Wischmeyer [48], in a meta-analysis including critically ill patients and trauma patients but excluding the recent Heyland study, concluded that IV glutamine should be added in PN in patients without renal and hepatic failure.…”

Section: Macronutrients Vitamins and Trace Elementsmentioning

confidence: 94%

Is Total Parenteral Nutrition (TPN) an Evil in Trauma Patients?

2016

View full text Add to dashboard Cite

The use of parenteral nutrition has been progressively decreasing over the past 30 years, and it has been considered as harmful while enteral feeding has been preferred for critically ill trauma patients, including for head trauma patients. However, the use of enteral feeding is associated with underfeeding while the use of parenteral nutrition can create complications due to overfeeding (infections, increased length of stay, length of ventilation, increased liver tests). Measuring energy expenditure by indirect calorimetry enables more accurate energy needs and calorie targets can be optimized. Formulas with higher protein content allow increased protein administration. In case of gastrointestinal intolerance, parenteral nutrition is an efficient alternative route to reach optimal targets. This route may improve clinical outcome. The use of parenteral nutrition has recently been shown to be safe if not given in excess, challenging the theory that TPN should be avoided. A reevaluation of the use of parenteral nutrition has to be performed to decrease calorie and nitrogen deficits in critically ill trauma patients.

show abstract

A randomized trial of intravenous glutamine supplementation in trauma ICU patients

Cited by 30 publications

References 36 publications

A randomized trial of intravenous glutamine supplementation in trauma ICU patients: response to the comments by Ozcelik et al.

A randomized trial of intravenous glutamine supplementation in trauma ICU patients: response to the comments by Ozcelik et al.

Enteral Nutrition Formula Selection

Is Total Parenteral Nutrition (TPN) an Evil in Trauma Patients?

Contact Info

Product

Resources

About