A randomized trial of a pre‐ and probiotic formula to reduce symptoms of dairy products in patients with dairy intolerance

Landon, Chris; Tran, Tracy; Connell, David B.

doi:10.1096/fasebj.20.5.a1053-c

Cited by 5 publications

(2 citation statements)

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“…However, the regular consumption of dairy products (and the associated calcium intake) is linked to positive health outcomes, such as reduced risk of osteoporosis and bone fractures ( 16 , 17 ). In addition, previous studies suggest that lactose tolerance can be acquired by lactose-intolerant individuals over a few weeks by the inclusion of regular or regularly increasing amounts of lactose in the diet ( 1 , 18 – 23 ).…”

Section: Introductionmentioning

confidence: 99%

Short-Term Dairy Product Elimination and Reintroduction Minimally Perturbs the Gut Microbiota in Self-Reported Lactose-Intolerant Adults

Smith

Dethlefsen

Gardner

et al. 2022

mBio

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Section: Introductionmentioning

confidence: 99%

Short-Term Dairy Product Elimination and Reintroduction Minimally Perturbs the Gut Microbiota in Self-Reported Lactose-Intolerant Adults

Smith

Dethlefsen

Gardner

et al. 2022

mBio

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“…The copyright holder for this preprint this version posted October 11, 2021. ; https://doi.org/10.1101/2021.10.10.463842 doi: bioRxiv preprint studies suggest that lactose tolerance can be acquired by lactose intolerant individuals over a few weeks by the inclusion of regular, or regularly increasing amounts of lactose in the diet. 1,[17][18][19][20][21][22] The importance of the role of the microbiota in health and disease is increasingly evident.…”

Section: Introductionmentioning

confidence: 99%

Short-Term Dairy Elimination and Reintroduction Minimally Perturbs the Gut Microbiota in Self-Reported Lactose Intolerant Adults

Smith

Dethlefsen

Gardner

et al. 2021

Preprint

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One of the outstanding questions regarding the human gut microbiota is how interventions designed to manipulate the microbiota may influence host phenotypic traits. Here, we employed a dietary intervention to probe this question in the context of lactose intolerance. To assess the effects of dairy elimination and reintroduction on the microbiota and host phenotype, we paired fecal 16S rRNA amplicon sequencing with a clinical assay for lactose intolerance, the hydrogen breath test. We studied 12 self-reported mildly lactose intolerant adults, each with tri-weekly collection of fecal samples over a 12-week study period (2 weeks baseline, 4 weeks of dairy elimination, 6 weeks of gradual milk reintroduction) and a hydrogen breath test before and after each phase. We found that although none of the subjects experienced a change in clinically defined status of lactose intolerant or tolerant, most subjects were qualitatively better able to tolerate dairy products with minimal symptoms at the end of the study compared to their baseline. Like clinical status, gut microbiota also resisted modification. Although the mean fraction of the genus Bifidobacterium, a group known to metabolize lactose, increased slightly with dairy reintroduction (from 0.0125 to 0.0206; Wilcoxon P = 0.068), the overall structure of each subject's gut microbiota remained highly individualized and largely stable. Our study is small, but it suggests the possibility of qualitatively improved tolerance in the absence of change in clinically defined tolerance nor major change in the gut microbiota.

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Nutrient Considerations in Lactose Intolerance

Hertzler

Savaiano

Jackson

et al. 2013

Nutrition in the Prevention and Treatment of Disease

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A randomized trial of a pre‐ and probiotic formula to reduce symptoms of dairy products in patients with dairy intolerance

Cited by 5 publications

References 0 publications

Short-Term Dairy Product Elimination and Reintroduction Minimally Perturbs the Gut Microbiota in Self-Reported Lactose-Intolerant Adults

Short-Term Dairy Product Elimination and Reintroduction Minimally Perturbs the Gut Microbiota in Self-Reported Lactose-Intolerant Adults

Short-Term Dairy Elimination and Reintroduction Minimally Perturbs the Gut Microbiota in Self-Reported Lactose Intolerant Adults

Nutrient Considerations in Lactose Intolerance

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