Background: Oral care is especially important in palliative care. Oral pain and adverse symptoms must be controlled during palliative care, because adequate communication with patients makes easy to perform good quality palliative care. In this case preserving verbal communication and comfortable mouth is very important. Aim: Our aim was to review the literature about the oral cavity complaints of patients with advanced cancer undergoing the pal-liative care, and to define which complaints are caused by direct impact of oncologic disease and which by the treatment methods. Materials and Methods: We reviewed most of the existing literature in this field. Unfortunately, there are not too much of publications about mouth problems of palliative patients with advanced cancer, but we used them to overview all known oral problems. Some of them report oral infections, some of them discuss the impact of the treatment methods and etc. We summarized all of them to create a real picture of oral cavity problems of palliative patients. Conclusion: Literature review proves that xerostomia, oral infections, taste alteration and other pathological conditions of oral cavity are very common in patients with advanced cancer. They lead to malnutrition and communication disorder and with the accompanying pathological condition decrease the quality of life. TCM-GMJ September 2017; 2(2):P20-P23)