A randomized study of simultaneous hCG administration with intrauterine insemination in stimulated cycles

Aydın, Yunus; Hassa, Hikmet; Öge, Tufan; Tokgöz, Vehbi Yavuz

doi:10.1016/j.ejogrb.2013.07.022

Cited by 20 publications

(19 citation statements)

References 23 publications

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“…In the study of Järvelä et al (7) pregnancy rate based on urine test was reported 10% and 19.6% in both standard and simultaneous respectively while this value was about 15% in both groups in our study. In the study of Aydin et al (8), although pregnancy was clinically evaluated, reported statistics were lower than our study (9.4% and 12.2%). Statistics of Mostafa et al (11) were 8% and 10% in the standard group and simultaneous group respectively.…”

Section: Discussioncontrasting

confidence: 83%

“…Statistics of Mostafa et al (11) were 8% and 10% in the standard group and simultaneous group respectively. Despite the differences in the overall statistics of pregnancy rate that it also seems pregnancy in standard IUI to be fewer than simultaneous IUI, it has not been observed in any of these studies (7,8,11). The only study similar to our study is the study of Rahman et al in India (9); in this study the pregnancy rate was reported about 30%.…”

Section: Discussioncontrasting

confidence: 50%

“…In the studies of Aydin et al In the standard and simultaneous groups of our study, pregnancy rate per patient were 26.6% and 21.3% (p= 0.54) respectively and pregnancy rate per IUI cycle were 16.15% and 15.2% (p= 0.87) respectively. In survey conducted in our study, like other studies (7,(8)(9)(10)(11), although there was no significant difference in pregnancy test between two groups, pregnancy rate in both groups was slightly higher than the previous studies (10). In the study of Järvelä et al (7) pregnancy rate based on urine test was reported 10% and 19.6% in both standard and simultaneous respectively while this value was about 15% in both groups in our study.…”

Section: Discussioncontrasting

confidence: 48%

“…In a study conducted by Ilkkay et al standard method of IUI that has been reported increased rate of pregnancy from 10.9% to 19.6% in simultaneous group (7). Another similar assessment in a clinical trial by Aydin et al (8) was performed on 220 couples in 2013 with male factor infertility or unknown causes. The patients were classified into two groups standard IUI (n= 106) and simultaneous IUI with HCG (n= 96).…”

Section: Discussionmentioning

confidence: 96%

See 3 more Smart Citations

Comparison of Pregnancy Rate in Simultaneous Human Chorionic Gonadotropin Administration with Intrauterine Insemination Vs. Standard intrauterine Insemination

Sahar¹,

Hamdi²,

Danaii³

et al. 2014

IJWHR

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Objective: Artificial insemination (AI) has been used to treat infertile couples for approximately 200 years. Time interval between administration of Human Chorionic Gonadotropin (HCG) and intrauterine insemination (IUI) is one of controversial subjects in AI. Fertility rate is in the highest level on the day before ovulation. The aim of study is to compare pregnancy rate in standard IUI versus simultaneous HCG administration with IUI. Materials and Methods: In a randomized, controlled clinical trial, 141 women 20-35 years selected for IUI among patients referring to infertility clinic of Al-Zahra hospital in Tabriz, Iran in 2013.they were entered into study in two groups of simultaneous (n= 71) and standard (n = 70). After ovulation stimulation by clomiphene and human menopausal gonadotropin (HMG) and creating up to 3 dominant follicles in each patient, a single dose of HCG was administered; thereafter, IUI was done in the simultaneous group instantly and 34-40 hours following HCG injection in the standard group. Results: In the standard and simultaneous groups, mean pregnancy rate per patient was 25.7% and 21.1% respectively (p= 0.52) and pregnancy rate per IUI cycle was 16.4% and 15.3% respectively (p= 0.82) that was not significantly different. Furthermore, between two groups in terms of age, the number of mature follicles, and endometrial thickness, there was no significant difference. Conclusion: Although difference in pregnancy rate between two groups was not statistically significant, simultaneous HCG with IUI is a comfort method for patients due to less cost and fewer patient's referrals to clinic.

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Section: Discussioncontrasting

confidence: 83%

Section: Discussioncontrasting

confidence: 50%

Section: Discussioncontrasting

confidence: 48%

Section: Discussionmentioning

confidence: 96%

See 2 more Smart Citations

Comparison of Pregnancy Rate in Simultaneous Human Chorionic Gonadotropin Administration with Intrauterine Insemination Vs. Standard intrauterine Insemination

Sahar¹,

Hamdi²,

Danaii³

et al. 2014

IJWHR

View full text Add to dashboard Cite

show abstract

“…On the other hand, in a randomized study by Aydin et al ., they compared the clinical pregnancy rate between IUIs with simultaneous hCG injection and IUIs performed at 34–36 h after hCG injection. They found no difference in clinical pregnancy rate between the two IUI groups . With these conflicting results, the Cochrane review concluded that although there exists an optimal window of several hours during which IUI can be performed, there is insufficient evidence to support any one timing over others …”

Section: Introductionmentioning

confidence: 99%