A Randomized Study of Biomimetic Peptides Efficacy and Impact on the Growth Factors Expression in the Hair Follicles of Patients with Telogen Effluvium

Abstract

Currently, biomimetic peptides have been developed to treat alopecia, which consists of amino acid residues and are able to selectively interact with cell receptors. This article studies the expression of growth factors (VEGF, KGF, EGF, TGF-β1) in the hair follicle of patients with telogen effluvium and healthy individuals and evaluating the efficacy of therapy with biomimetic peptides in patients with telogen effluvium based on clinical data and the dynamics. The method of immunofluorescence study of scalp specimens, which is taken by the punch biopsy from the frontotemporal areas before and after the therapy, was used. 30 female patients with telogen effluvium aged between 20 and 56 years old were recruited for the research and randomly divided into two groups. Patients of group I were treated with lotion based on biomimetic peptides and those of group II were treated with 0.9% saline. The therapeutic efficacy of biomimetic peptides in women with telogen effluvium was assessed by trichoscopy and phototrichography. A change in the expression of VEGF, KGF, TGF-β1 growth factors was found in women with telogen effluvium as opposed to the healthy ones. After the therapy, a significant increase in the VEGF, EGF expression and a decrease in KGF and TGF-β1 expression were noted. The study proved the effectiveness of the proposed method of therapy for women with telogenic effluvium. The research findings can be useful to dermatologists and cosmetologists for increasing the effectiveness of therapy for patients with telogenic effluvium. Also, the data obtained in the article open up the prospect for the further study of the pathogenetic mechanisms of telogenic effluvium and provide an opportunity for an innovative approach to the therapy of patients with telogenic effluvium.

Re-Densification Effect of Pressure-Injected Peptide-Hyaluronic Acid Combination on Male Androgenic Alopecia

“…Nam [14] revealed suppressed apoptosis of DHT-treated human dermal papilla cells by applying a synthesized AC2 peptide. In the study of female telogen effluvium, using a lotion containing peptide combination (decapeptide-18, oligopeptide-54, decapeptide-10, octapeptide-2, decapeptide-19, oligopeptide-71, and decapeptide-28) Kubanov [15] demonstrated a statistically significant decrease in the proportion of telogen hairs and a statistical increase in the proportion of anagen hairs. Rinaldi [16] showed hair re-growth in alopecia patches injected with BP mimicking autologous platelet-rich plasma (octapeptide-2, decapeptide-3, copper tripeptide-1, and oligopeptide-20).…”

Growth Factors and Microneedling in Alopecia Areata: A Narrative Review

“…Growth factors can cause the vascular endothelium and dermal fibroblasts to proliferate, extend the anagen phase, and delay the initiation of catagen in hair follicles. Thus, with the aid of these growth factors, anagen can be prolonged, and hair growth can be promoted [9]. Therefore, growth factors may be important molecules that play a role in the initiation and termination of the regular hair growth cycle [9].…”

“…Thus, with the aid of these growth factors, anagen can be prolonged, and hair growth can be promoted [9]. Therefore, growth factors may be important molecules that play a role in the initiation and termination of the regular hair growth cycle [9].…”