A randomized sham controlled comparison of once vs twice-daily intermittent theta burst stimulation in depression: A Canadian rTMS treatment and biomarker network in depression (CARTBIND) study

Abstract

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Twice daily low frequency rTMS for treatment-resistant auditory hallucinations

“…In addition, although most of the TMS clinical studies have used once-daily sessions of rTMS, we proposed to deliver sessions twice-daily in line with our previous studies in schizophrenia ( Brunelin et al., 2022 , Poulet et al., 2005 ). Some studies in depression have directly compared once- to twice-daily protocols while matching the same total number of pulses and showed nonsignificant differences in final response or remission rates between conditions ( Blumberger et al., 2021 ; Schulze et al., 2018 ), however, clinical improvement was faster ( Schulze et al., 2018 ) and tends to be stronger ( Modirrousta et al., 2018 ) with twice-daily sessions. Repeating sessions twice daily, which can be considered an 'accelerated' protocol of rTMS ( Caulfield et al., 2022 ), is relevant to clinical practice because it reduces the number of days patients need to visit the clinical unit and thus can potentially increase adherence to treatment in certain clinical populations such as patients with schizophrenia ( Brunelin et al., 2022 ).…”

Does switching between high frequency rTMS and theta burst stimulation improve depression outcomes?

“…We read with interest recent articles in Brain Stimulation, reporting on the antidepressant effects of theta burst stimulation (TBS) applied in accelerated schedules [1,2] and the efficacy comparison between unilateral and bilateral repetitive transcranial magnetic stimulation (rTMS) approaches [3]. We recently reported a multisite randomized controlled trial comparing the antidepressant efficacy of accelerated bilateral TBS applied at 80% or 120% of the resting motor threshold (RMT) and left-sided 10 Hz rTMS applied at 120% RMT [4].…”

Metaplasticity and non-invasive brain stimulation: the search for new biomarkers and directions for therapeutic neuromodulation

“…16, № 3. DOI: https://doi.org/10.54101/ACEN.2022.3.9 с имитацией стимуляции [90][91][92][93] или стандартной ТМС [94]. Среди исследований с негативным результатом следует отметить работу P.B.…”